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Iain P. Hargreaves
Researcher at Liverpool John Moores University
Publications - 180
Citations - 9453
Iain P. Hargreaves is an academic researcher from Liverpool John Moores University. The author has contributed to research in topics: Mitochondrial disease & Coenzyme Q10. The author has an hindex of 42, co-authored 166 publications receiving 8044 citations. Previous affiliations of Iain P. Hargreaves include UCL Institute of Neurology & University College Hospital.
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Journal ArticleDOI
Association between mitochondrial dysfunction and severity and outcome of septic shock
David Brealey,M. P. Brand,Iain P. Hargreaves,Simon J.R. Heales,John M. Land,Ryszard T. Smolenski,Nathan Davies,Chris E. Cooper,Mervyn Singer +8 more
TL;DR: In septic patients, an association between nitric oxide overproduction, antioxidant depletion, mitochondrial dysfunction, and decreased ATP concentrations that relate to organ failure and eventual outcome is found.
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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
Patrick J. Pollard,J. J. Briere,N. A. Alam,J Barwell,Ella Barclay,Noel C. Wortham,Tim Hunt,M. Mitchell,Simon E. Olpin,Stuart James Moat,Iain P. Hargreaves,S. J. Heales,Yuen-Li Chung,John R. Griffiths,A. Dalgleish,John A. McGrath,Michael Gleeson,Shirley Hodgson,Richard Poulsom,Pierre Rustin,I. P. M. Tomlinson +20 more
TL;DR: In this study, it is shown that FH-deficient cells and tumours accumulate fumarate and, to a lesser extent, succinate, and in situ analyses showed that these tumours also have over-expression of hypoxia-inducible factor 1alpha, activation of HIF1alphatargets, and high microvessel density.
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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
L. Miguel Martins,L. Miguel Martins,Alastair Morrison,Kristina Klupsch,Valentina Fedele,Nicoleta Moisoi,Peter Teismann,Alejandro Abuin,Evelyn Grau,Martin Geppert,George P. Livi,Caretha L. Creasy,Alison Martin,Iain P. Hargreaves,Simon J.R. Heales,Hitoshi Okada,Sebastian Brandner,Jörg B. Schulz,Tak W. Mak,Julian Downward +19 more
TL;DR: Mammalian HtrA2/Omi is likely to function in vivo in a manner similar to that of its bacterial homologues DegS and DegP, which are involved in protection against cell stress, and not like the proapoptotic Reaper family proteins in Drosophila melanogaster.
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Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
Kira M. Holmström,Liam Baird,Ying Zhang,Iain P. Hargreaves,Annapurna Chalasani,John M. Land,Lee Stanyer,Masayuki Yamamoto,Albena T. Dinkova-Kostova,Albena T. Dinkova-Kostova,Andrey Y. Abramov +10 more
TL;DR: A novel role is demonstrated for Nrf2 in directly regulating mitochondrial bioenergetics in murine neurons and embryonic fibroblasts through modulating the availability of substrates for mitochondrial respiration and the importance of efficient energy metabolism in NRF2-mediated cytoprotection.
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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.
Alison Wood-Kaczmar,Sonia Gandhi,Zhi Yao,Andrey Y. Abramov,Erik Miljan,Gregory Keen,Lee Stanyer,Iain P. Hargreaves,Kristina Klupsch,Emma Deas,Julian Downward,Louise Mansfield,Parmjit S. Jat,Joanne Taylor,Simon J.R. Heales,Michael R. Duchen,David S. Latchman,Sarah J. Tabrizi,Nicholas W. Wood +18 more
TL;DR: It is reported that PINK1 plays a neuroprotective role in the mitochondria of mammalian neurons, especially against stress such as staurosporine, and evidence that cellular compensatory mechanisms such as mitochondrial biogenesis and upregulation of lysosomal degradation pathways occur in Pink1 deficiency.