Ying Zhang

TL;DR: It is suggested that the Keap1–Nrf2 pathway regulates both mitochondrial and cytosolic ROS production through NADPH oxidase, which supports a key role of the KeAP1-NRF2 pathway in redox homeostasis within the cell.

TL;DR: A novel role is demonstrated for Nrf2 in directly regulating mitochondrial bioenergetics in murine neurons and embryonic fibroblasts through modulating the availability of substrates for mitochondrial respiration and the importance of efficient energy metabolism in NRF2-mediated cytoprotection.

TL;DR: The mitochondrial oxidation of long-chain and short-chain fatty acids is depressed in the absence of NRF2 and accelerated when Nrf2 is constitutively active, which has implications for chronic disease conditions including cancer, metabolic syndrome and neurodegeneration.

TL;DR: Evaluation in various cell lines including hepatoma cells, retinal pigment epithelial cells, and keratinocytes as well as in mouse skin shows that sulfoxythiocarbamate analogs maintain high potency and efficacy for phase 2 enzyme induction aswell as the inhibitory effect on lipopolysaccharide-induced nitric oxide formation like sulforaphane.

TL;DR: Novel monocyclic cyano enones, representing fragments of rings A and C of the tricyclic compound, reveal that the contribution to inducer potency of the ring C Michael acceptor is much greater than that of ring A, and that potency is further enhanced by spatial proximity of an acetylenic function.