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Annapurna Chalasani
Researcher at University College London
Publications - 12
Citations - 718
Annapurna Chalasani is an academic researcher from University College London. The author has contributed to research in topics: Mitochondrial disease & Cerebellar ataxia. The author has an hindex of 8, co-authored 12 publications receiving 579 citations. Previous affiliations of Annapurna Chalasani include Moorfields Eye Hospital.
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Journal ArticleDOI
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
Kira M. Holmström,Liam Baird,Ying Zhang,Iain P. Hargreaves,Annapurna Chalasani,John M. Land,Lee Stanyer,Masayuki Yamamoto,Albena T. Dinkova-Kostova,Albena T. Dinkova-Kostova,Andrey Y. Abramov +10 more
TL;DR: A novel role is demonstrated for Nrf2 in directly regulating mitochondrial bioenergetics in murine neurons and embryonic fibroblasts through modulating the availability of substrates for mitochondrial respiration and the importance of efficient energy metabolism in NRF2-mediated cytoprotection.
Journal ArticleDOI
Genetic dysfunction of MT-ATP6 causes axonal Charcot-Marie-Tooth disease
Robert D S Pitceathly,Sinéad M. Murphy,E. Cottenie,Annapurna Chalasani,Mary G. Sweeney,Cathy E. Woodward,Ese E. Mudanohwo,Iain P. Hargreaves,Simon Heales,John M. Land,Janice L. Holton,Henry Houlden,Julian Blake,Julian Blake,Michael Champion,Frances Flinter,Stephanie A. Robb,Rupert Page,Michael Rose,Jacqueline Palace,Carol Crowe,Cheryl Longman,Michael P. Lunn,Shamima Rahman,Mary M. Reilly,Mary M. Reilly,Michael G. Hanna +26 more
TL;DR: Recognition that mutations in MT-ATP6 cause CMT2 enhances current understanding of the pathogenic basis of axonal neuropathy, and has important implications for diagnosis and genetic counseling.
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Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.
Rojeen Shahni,Catherine M. Cale,Glenn Anderson,Laura D. Osellame,Sophie Hambleton,Thomas S. Jacques,Thomas S. Jacques,Yehani Wedatilake,Jan-Willem Taanman,Emma Chan,Waseem Qasim,Vincent Plagnol,Annapurna Chalasani,Michael R. Duchen,Kimberley Gilmour,Shamima Rahman +15 more
TL;DR: A novel mutation in STAT2, which encodes a component of the JAK-STAT cytokine signalling pathway, is identified in three patients with severe neurological deterioration following viral infection, suggesting a new avenue for treatment of mitochondrial diseases and possibly common neurodegenerative disorders.
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Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment.
Kate Duberley,Andrey Y. Abramov,Annapurna Chalasani,Simon Heales,Shamima Rahman,Shamima Rahman,Iain P. Hargreaves +6 more
TL;DR: A neuronal cell model of CoQ10 deficiency is established by treatment of neuronal SH-SY5Y cell line with para-aminobenzoic acid, providing insights into the effects of coenzyme Q10 deficiency on neuronal mitochondrial function and oxidative stress.
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Autosomal-recessive cerebellar ataxia caused by a novel ADCK3 mutation that elongates the protein: clinical, genetic and biochemical characterisation
Yo-Tsen Liu,Joshua Hersheson,Vincent Plagnol,Katherine A. Fawcett,Kate Duberley,Elisavet Preza,Iain P. Hargreaves,Annapurna Chalasani,Matilde Laura,Nicholas W. Wood,Mary M. Reilly,Henry Houlden +11 more
TL;DR: A novel homozygous frameshift mutation in ADCK3, which results in the loss of the stop codon, is identified in both siblings and broadens the phenotypic spectrum associated with ADCk3 mutations and provides further understanding of their pathogenic mechanism.