Ian C. G. Weaver

TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.

TL;DR: It is reported that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 17 promoter, GR expression, and hypothalamic-pituitary-adrenal and behavioral responses to stress, suggesting a causal relationship among epigenomic state, GRexpression, and stress responses in the adult offspring.

TL;DR: It is reported that TSA and methionine treatment reversed the effect of maternal care on open-field behavior, and >900 genes stably regulated by maternal care were identified.

TL;DR: In the present studies, cross-fostering confirmed an association between maternal care and ERα expression in the MPOA; the biological offspring of low LG mothers fostered at birth to high LG dams show increased ERα Expression in theMPOA.

TL;DR: Site-directed mutagenesis assays demonstrate that NGFI-A binding to the exon 17 GR promoter is required for epigenetic reprogramming of GR expression, and Knockdown experiments of NGfi-A in hippocampal primary cell culture show that NG FI-A is necessary for serotonin-induced DNA demethylation and increased exon17 GR promoter expression.