S
Sergiy Dymov
Researcher at McGill University
Publications - 14
Citations - 11027
Sergiy Dymov is an academic researcher from McGill University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 11, co-authored 13 publications receiving 10331 citations.
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Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Ana C. D'Alessio,Sergiy Dymov,Benoit Labonté,Moshe Szyf,Gustavo Turecki,Michael J. Meaney,Michael J. Meaney +9 more
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
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Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
Ian C. G. Weaver,Frances A. Champagne,Shelley E. Brown,Sergiy Dymov,Shakti Sharma,Michael J. Meaney,Moshe Szyf +6 more
TL;DR: It is reported that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 17 promoter, GR expression, and hypothalamic-pituitary-adrenal and behavioral responses to stress, suggesting a causal relationship among epigenomic state, GRexpression, and stress responses in the adult offspring.
Journal ArticleDOI
Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring
Frances A. Champagne,Ian C. G. Weaver,Josie Diorio,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +5 more
TL;DR: In the present studies, cross-fostering confirmed an association between maternal care and ERα expression in the MPOA; the biological offspring of low LG mothers fostered at birth to high LG dams show increased ERα Expression in theMPOA.
Journal ArticleDOI
The Transcription Factor Nerve Growth Factor-Inducible Protein a Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes
Ian C. G. Weaver,Ana C. D'Alessio,Shelley E. Brown,Ian C. Hellstrom,Sergiy Dymov,Shakti Sharma,Moshe Szyf,Michael J. Meaney +7 more
TL;DR: Site-directed mutagenesis assays demonstrate that NGFI-A binding to the exon 17 GR promoter is required for epigenetic reprogramming of GR expression, and Knockdown experiments of NGfi-A in hippocampal primary cell culture show that NG FI-A is necessary for serotonin-induced DNA demethylation and increased exon17 GR promoter expression.