M
Moshe Szyf
Researcher at McGill University
Publications - 363
Citations - 40843
Moshe Szyf is an academic researcher from McGill University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 92, co-authored 347 publications receiving 37601 citations. Previous affiliations of Moshe Szyf include University of British Columbia & Hebrew University of Jerusalem.
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Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Ana C. D'Alessio,Sergiy Dymov,Benoit Labonté,Moshe Szyf,Gustavo Turecki,Michael J. Meaney,Michael J. Meaney +9 more
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
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Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
Ian C. G. Weaver,Frances A. Champagne,Shelley E. Brown,Sergiy Dymov,Shakti Sharma,Michael J. Meaney,Moshe Szyf +6 more
TL;DR: It is reported that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 17 promoter, GR expression, and hypothalamic-pituitary-adrenal and behavioral responses to stress, suggesting a causal relationship among epigenomic state, GRexpression, and stress responses in the adult offspring.
Journal ArticleDOI
Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.
Michael J. Meaney,Moshe Szyf +1 more
TL;DR: It is demonstrated that the structural modifications of the DNA can be established through environmental programming and that, in spite of the inherent stability of this epigenomic marker, it is dynamic and potentially reversible.
Journal ArticleDOI
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
TL;DR: It is reported that TSA and methionine treatment reversed the effect of maternal care on open-field behavior, and >900 genes stably regulated by maternal care were identified.