S
Shakti Sharma
Researcher at McGill University
Publications - 33
Citations - 17601
Shakti Sharma is an academic researcher from McGill University. The author has contributed to research in topics: Corticosterone & Glucocorticoid. The author has an hindex of 30, co-authored 33 publications receiving 16872 citations. Previous affiliations of Shakti Sharma include Emory University & Douglas Mental Health University Institute.
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Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Dong Liu,Josie Diorio,Josie Diorio,Beth Tannenbaum,Beth Tannenbaum,Christian Caldji,Christian Caldji,Darlene D. Francis,Darlene D. Francis,Alison Freedman,Alison Freedman,Shakti Sharma,Shakti Sharma,Deborah Pearson,Deborah Pearson,Paul M. Plotsky,Paul M. Plotsky,Michael J. Meaney,Michael J. Meaney +18 more
TL;DR: It is suggested that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.
Journal ArticleDOI
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat
Christian Caldji,Beth Tannenbaum,Shakti Sharma,Darlene D. Francis,Paul M. Plotsky,Michael J. Meaney +5 more
TL;DR: It is suggested that maternal care during infancy serves to "program" behavioral responses to stress in the offspring by altering the development of the neural systems that mediate fearfulness.
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Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress.
Michael J. Meaney,Josie Diorio,Darlene D. Francis,Judith Widdowson,Patricia Laplante,Christian Caldji,Shakti Sharma,Jonathan R. Seckl,Paul M. Plotsky +8 more
TL;DR: The findings indicate that the early postnatal environment alters the differentiation of hippocampal neurons, and these data provide examples of early environmental programming of neural systems.
Journal ArticleDOI
Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
Ian C. G. Weaver,Frances A. Champagne,Shelley E. Brown,Sergiy Dymov,Shakti Sharma,Michael J. Meaney,Moshe Szyf +6 more
TL;DR: It is reported that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 17 promoter, GR expression, and hypothalamic-pituitary-adrenal and behavioral responses to stress, suggesting a causal relationship among epigenomic state, GRexpression, and stress responses in the adult offspring.