F
Frances A. Champagne
Researcher at University of Texas at Austin
Publications - 142
Citations - 23353
Frances A. Champagne is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Offspring & Epigenetics. The author has an hindex of 60, co-authored 129 publications receiving 21225 citations. Previous affiliations of Frances A. Champagne include McGill University & University of Cambridge.
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Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Variations in maternal care in the rat as a mediating influence for the effects of environment on development.
TL;DR: Findings indicate considerable, normal variations in licking/grooming in the rat that are a stable, individual characteristic of rat dams.
Journal ArticleDOI
Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
Ian C. G. Weaver,Frances A. Champagne,Shelley E. Brown,Sergiy Dymov,Shakti Sharma,Michael J. Meaney,Moshe Szyf +6 more
TL;DR: It is reported that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 17 promoter, GR expression, and hypothalamic-pituitary-adrenal and behavioral responses to stress, suggesting a causal relationship among epigenomic state, GRexpression, and stress responses in the adult offspring.
Journal ArticleDOI
Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits
Guomei Tang,Kathryn Gudsnuk,Sheng-Han Kuo,Marisa L. Cotrina,Marisa L. Cotrina,Gorazd Rosoklija,Alexander A. Sosunov,Mark S. Sonders,Ellen Kanter,Candace Castagna,Ai Yamamoto,Zhenyu Yue,Ottavio Arancio,Bradley S. Peterson,Frances A. Champagne,Andrew J. Dwork,James E. Goldman,David Sulzer +17 more
TL;DR: This work reports increased dendritic spine density with reduced developmental spine pruning in layer V pyramidal neurons in postmortem ASD temporal lobe and suggests that mTOR-regulated autophagy is required for developmental spinePruning, and activation of neuronal Autophagy corrects synaptic pathology and social behavior deficits in ASD models with hyperactivated mTOR.
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Epigenetic mechanisms and the transgenerational effects of maternal care.
TL;DR: Evidence for the generational transmission of maternal care and the mechanisms underlying this transmission will be discussed as will the implications of this inheritance system for offspring development and for the transmission of environmental information from parents to offspring.