Adipose-Derived Stem Cells in Crohn's Rectovaginal Fistula
Dolores C. García-Olmo,Dolores Herreros,Paloma De-La-Quintana,Héctor Guadalajara,Jacobo Trébol,T. Georgiev-Hristov,Mariano García-Arranz +6 more
TLDR
The conclusion of the study with Mary is that the use of mesenchymal stem cells derived from adipose tissue is secure, either in autologous or allogeneic form, which confirms the safety of using these cells in patients at least in the fistulizing Crohn's disease environment.Abstract:
Therapeutic options for recto-vaginal fistula in the setting of Crohn's disease are limited and many data are available in the literature. The manuscript describes the history of a patient who has been the pioneer of our Clinical Trials in treating this disease in fistulizing Crohn's disease environment. We believe it is the first time that a patient with this disease has been treated by adipose-derived stem cells in allogeneic form. The conclusion of our study with Mary is that the use of mesenchymal stem cells derived from adipose tissue is secure, either in autologous or allogeneic form. Furthermore, we have proved that if we use multi-dose and multiple applications on a patient, it does not produce any adverse effect, which confirms us the safety of using these cells in patients at least in the fistulizing Crohn's disease environment.read more
Citations
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Journal ArticleDOI
Autologous adipose tissue‐derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula
Woo Yong Lee,Kyu Joo Park,Yong Beom Cho,Sang Nam Yoon,Kee Ho Song,Do Sun Kim,Sang Hun Jung,Mihyung Kim,Hee Won Yoo,Inok Kim,Hunjoo Ha,Chang Sik Yu +11 more
TL;DR: Autologous ASC treatment for patients with Crohn's fistulae was well tolerated, with a favorable therapeutic outcome, and complete closure was well sustained, suggesting that autologousASC could be a novel treatment option for the Crohn’s fistula with high‐risk of recurrence.
Journal ArticleDOI
Regenerative Capacity of Adipose Derived Stem Cells (ADSCs), Comparison with Mesenchymal Stem Cells (MSCs).
TL;DR: This review analyzed the therapeutic advancement of ADSCs in comparison to bone marrow (BM) and umbilical cord (UC)-mesenchymal stem cells (MSCs) and designed the specific requirements to their best clinical practices and safety.
Journal ArticleDOI
Human adipose stem cells: current clinical applications.
Phanette Gir,Georgette Oni,Georgette Oni,Spencer A. Brown,Spencer A. Brown,Ali Mojallal,Ali Mojallal,Rod J. Rohrich +7 more
TL;DR: The results of the studies and clinical trials reported in this review seem to be promising not only in plastic surgery but also in a wide variety of other specialties, Nevertheless, those reported showed disparity in the way adipose-derived stem cells were used.
Journal ArticleDOI
Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine.
Emanuela Sala,Marco Genua,Luciana Petti,Achille Anselmo,V. Arena,Javier Cibella,Lucia Zanotti,Silvia D'Alessio,Franco Scaldaferri,Giovanni Luca,Iva Arato,Riccardo Calafiore,Alessandro Sgambato,Sergio Rutella,Massimo Locati,Silvio Danese,Stefania Vetrano +16 more
TL;DR: BM-MSCs injected into mice with colitis do not localize to the intestine but instead form aggregates in the peritoneum where they produce immunoregulatory molecules, including TSG6, that reduce intestinal inflammation.
Journal ArticleDOI
Adipose-Derived Stem Cells in Tissue Regeneration: A Review
TL;DR: The progress made in the ASC field since their initial description is outlined, describing their mesodermal, ectoder mal, and endodermal potentials both in vitro and in vivo, their use in mediating inflammation and vascularization during tissue regeneration, and their potential for reprogramming into induced pluripotent cells.
References
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The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients
Jean-Frederic Colombel,Edward V. Loftus,William J. Tremaine,Laurence J. Egan,W. Scott Harmsen,Cathy D. Schleck,Alan R. Zinsmeister,William J. Sandborn +7 more
TL;DR: Short- and long-term infliximab therapy is generally well tolerated, however, clinicians must be vigilant for the occurrence of infrequent but serious events, including serum sickness-like reaction, opportunistic infection and sepsis, and autoimmune disorders.
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A Phase I Clinical Trial of the Treatment of Crohn’s Fistula by Adipose Mesenchymal Stem Cell Transplantation
Damián García-Olmo,Mariano García-Arranz,Dolores Herreros,Isabel Pascual,Concepción Peiró,José Antonio Rodríguez-Montes,José Antonio Rodríguez-Montes +6 more
TL;DR: The results indicate that the protocol is feasible and safe for the treatment of fistulas in Crohn’s disease, and is the first report of a clinical trial of cell therapy using autologous stem cells obtained from a lipoaspirate.
Journal ArticleDOI
Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial.
Damián García-Olmo,Dolores Herreros,Isabel Pascual,José Antonio Pascual,Emilio Del-Valle,Jaime Zorrilla,Paloma De-La-Quintana,Mariano García-Arranz,Maria Pascual +8 more
TL;DR: Administration of expanded ASCs (20 to 60 million cells) in combination with fibrin glue is an effective and safe treatment for complex perianal fistula and appears to achieve higher rates of healing than fibr in glue alone.
Journal ArticleDOI
Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis
TL;DR: Systemic infusion of ASCs significantly ameliorated the clinical and histopathological severity of colitis, abrogating weight loss, diarrhoea and inflammation, and increasing survival and ASCs protected from severe sepsis by reducing the infiltration of inflammatory cells in various target organs and by downregulating the production of various inflammatory mediators.
Journal ArticleDOI
Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy.
Damián García-Olmo,Mariano García-Arranz,Lourdes Gómez García,Eduardo Serna Cuellar,Ignacio Fernández Blanco,Luis Asensio Prianes,José Antonio Rodríguez Montes,Francisca Lima Pinto,Dolores Herreros Marcos,Luis García-Sancho +9 more
TL;DR: Cell transplantation to overcome healing problems is a new surgical tool, and careful evaluation of this new modality may provide an opportunity to define a new era in the treatment of surgical challenges associated with healing disorders.