Jeff Reeve

TL;DR: This prospective cohort indicates that many actual failures after indication biopsies manifest phenotypic features of antibody‐mediated or mixed rejection and also underscores the major role of nonadherence.

TL;DR: The major cause of late kidney transplant failure is antibody‐mediated microcirculation injury, but detection of this phenotype requires new diagnostic criteria.

TL;DR: De novo DSA at the time of a late biopsy for clinical indication is primarily against class II, and associates with microcirculation changes in the biopsy and subsequent graft failure, and is proposed to be performed in all late kidney transplants.

TL;DR: It is concluded that microarray assessment of gene expression can assign a probability of ABMR to transplant biopsies without knowledge of HLA antibody status, histology, or C4d staining, and predicts future failure.

TL;DR: Many transcriptome changes previously described in rejection are features of a large‐scale disturbance characteristic of rejection but occurring at lower levels in many forms of injury, indicating that transcriptome disturbances in renal transplants have a stereotyped internal structure.