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Junichiro James Kazama

Researcher at Fukushima Medical University

Publications -  212
Citations -  5725

Junichiro James Kazama is an academic researcher from Fukushima Medical University. The author has contributed to research in topics: Kidney disease & Hyperparathyroidism. The author has an hindex of 38, co-authored 191 publications receiving 4952 citations. Previous affiliations of Junichiro James Kazama include Niigata University.

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Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency.

TL;DR: FGF-23 becomes a potential uremic toxin to decrease 1,25D levels when it loses its hypophosphatemic action because of a decreased number of viable nephrons in patients with advanced renal failure and may be an important determinant in the regulation of mineral metabolism with renal insufficiency.
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Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients

TL;DR: Serum FGF-23 level was found to be the most useful factor in predicting future development of refractory secondary hyper parathyroidism in long-term dialysis patients with mild secondary hyperparathyroidistan.
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Increased circulating levels of osteoclastogenesis inhibitory factor (osteoprotegerin) in patients with chronic renal failure.

TL;DR: It is suggested that OCIF accumulates in serum of patients with renal dysfunction, and may be a candidate uremic toxin responsible for the skeletal resistance to PTH seen in chronic renal failure.