K
Khusru Asadullah
Researcher at Schering AG
Publications - 69
Citations - 9777
Khusru Asadullah is an academic researcher from Schering AG. The author has contributed to research in topics: Psoriasis & Cytokine. The author has an hindex of 31, co-authored 62 publications receiving 9185 citations.
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Journal ArticleDOI
Mechanisms involved in the side effects of glucocorticoids
TL;DR: This review summarizes the current knowledge of the most important GC-mediated side effects from a clinical to a molecular perspective and should be helpful in predicting the potential advantages of selective GR agonists in comparison to classical GCs.
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IL-22 increases the innate immunity of tissues.
Kerstin Wolk,Stefanie Kunz,Ellen Witte,Markus Friedrich,Khusru Asadullah,Robert Sabat,Robert Sabat +6 more
TL;DR: IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues.
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Interleukin-10 Therapy—Review of a New Approach
TL;DR: New insight is given into the immunobiology of IL-10 and it is suggested that the IL- 10/IL-10 receptor system may become a new therapeutic target.
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IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes : a potential role in psoriasis
Kerstin Wolk,Ellen Witte,Elizabeth Wallace,Wolf-Dietrich Döcke,Stefanie Kunz,Khusru Asadullah,Hans-Dieter Volk,Wolfram Sterry,Robert Sabat +8 more
TL;DR: It is demonstrated that IL‐22, in contrast to its relative IFN‐γ, regulates the expression of only a few genes in keratinocytes, which may be important in the innate immunity and reorganization of epithelia.
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Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?
TL;DR: Investigation of the expression of five novel human IL-10-related molecules and their receptors in blood mononuclear cells found IL-19 and IL-20 were found to be preferentially expressed in monocytes, and monocytes and NK, B, and T cells showed clear expression only of IL- 10R1,IL-10R2, andIL-20R2.