H
Hans-Dieter Volk
Researcher at Charité
Publications - 809
Citations - 51738
Hans-Dieter Volk is an academic researcher from Charité. The author has contributed to research in topics: Transplantation & Immune system. The author has an hindex of 107, co-authored 784 publications receiving 46622 citations. Previous affiliations of Hans-Dieter Volk include National Institutes of Health & Cleveland Clinic Lerner Research Institute.
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Journal ArticleDOI
Monocyte deactivation in septic patients: restoration by IFN-gamma treatment.
Wolf-Dietrich Döcke,Felix Randow,Uta Syrbe,Dietmar Krausch,Khusru Asadullah,Petre Reinke,Hans-Dieter Volk,Wolfgang J. Kox +7 more
TL;DR: Recovery of monocyte function resulted in clearance of sepsis in eight of nine patients and suggests that IFN-γ treatment in carefully selected septic patients is a novel therapeutic strategy worth pursuing.
Journal ArticleDOI
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Jonas Schulte-Schrepping,Nico Reusch,Daniela Paclik,Kevin Baßler,Stephan Schlickeiser,Bowen Zhang,Benjamin Krämer,Tobias Krammer,Sophia Brumhard,Lorenzo Bonaguro,Elena De Domenico,Daniel Wendisch,Martin Grasshoff,Theodore S. Kapellos,Michael Beckstette,Tal Pecht,Adem Saglam,Oliver Dietrich,Henrik E. Mei,Axel Schulz,Claudia Conrad,Désirée Kunkel,Ehsan Vafadarnejad,Cheng-Jian Xu,Cheng-Jian Xu,Arik Horne,Miriam Herbert,Anna Drews,Charlotte Thibeault,Moritz Pfeiffer,Stefan Hippenstiel,Andreas C. Hocke,Holger Müller-Redetzky,Katrin-Moira Heim,Felix Machleidt,Alexander Uhrig,Laure Bosquillon de Jarcy,Linda Jürgens,Miriam Stegemann,Christoph R. Glösenkamp,Hans-Dieter Volk,Christine Goffinet,Markus Landthaler,Emanuel Wyler,Philipp Georg,Maria Schneider,Chantip Dang-Heine,Nick Neuwinger,Kai Kappert,Rudolf Tauber,Victor M. Corman,Jan Raabe,Kim Melanie Kaiser,Michael To Vinh,Gereon Rieke,Christian Meisel,Thomas Ulas,Matthias Becker,Robert Geffers,Martin Witzenrath,Christian Drosten,Norbert Suttorp,Christof von Kalle,Florian Kurth,Florian Kurth,Florian Kurth,Kristian Händler,Joachim L. Schultze,Joachim L. Schultze,Anna C. Aschenbrenner,Anna C. Aschenbrenner,Yang Li,Yang Li,Jacob Nattermann,Birgit Sawitzki,Antoine-Emmanuel Saliba,Leif E. Sander,Angel Angelov,Robert Bals,Alexander Bartholomäus,Anke Becker,Daniela Bezdan,Ezio Bonifacio,Peer Bork,Thomas Clavel,Maria Colomé-Tatché,Andreas Diefenbach,Alexander T. Dilthey,Nicole Fischer,Konrad U. Förstner,Julia-Stefanie Frick,Julien Gagneur,Alexander Goesmann,Torsten Hain,Michael Hummel,Stefan Janssen,Jörn Kalinowski,René Kallies,Birte Kehr,Andreas Keller,Sarah Kim-Hellmuth,Christoph Klein,Oliver Kohlbacher,Jan O. Korbel,Ingo Kurth,Kerstin U. Ludwig,Oliwia Makarewicz,Manja Marz,Alice C. McHardy,Christian Mertes,Markus M. Nöthen,Peter Nürnberg,Uwe Ohler,Stephan Ossowski,Jörg Overmann,Silke Peter,Klaus Pfeffer,Anna R. Poetsch,Alfred Pühler,Nikolaus Rajewsky,Markus Ralser,Olaf Rieß,Stephan Ripke,Ulisses Nunes da Rocha,Philip Rosenstiel,Philipp H. Schiffer,Eva-Christina Schulte,Alexander Sczyrba,Oliver Stegle,Jens Stoye,Fabian J. Theis,Janne Vehreschild,Jörg Vogel,Max von Kleist,Andreas Walker,Jörn Walter,Dagmar Wieczorek,John Ziebuhr +137 more
TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
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Interleukin-10 Therapy—Review of a New Approach
TL;DR: New insight is given into the immunobiology of IL-10 and it is suggested that the IL- 10/IL-10 receptor system may become a new therapeutic target.
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IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes : a potential role in psoriasis
Kerstin Wolk,Ellen Witte,Elizabeth Wallace,Wolf-Dietrich Döcke,Stefanie Kunz,Khusru Asadullah,Hans-Dieter Volk,Wolfram Sterry,Robert Sabat +8 more
TL;DR: It is demonstrated that IL‐22, in contrast to its relative IFN‐γ, regulates the expression of only a few genes in keratinocytes, which may be important in the innate immunity and reorganization of epithelia.
Journal ArticleDOI
Endotoxin and immune activation in chronic heart failure: a prospective cohort study.
Josef Niebauer,Hans-Dieter Volk,Michael Kemp,Martin Dominguez,Ralf R. Schumann,Mathias Rauchhaus,Philip A. Poole-Wilson,Andrew J.S. Coats,Stefan D. Anker,Stefan D. Anker +9 more
TL;DR: Raised concentrations of endotoxin and cytokines are found in patients with chronic heart failure during acute oedematous exacerbation and the preliminary findings suggest that endotoxin may trigger immune activation in patientsWith chronic heart fail, intensified diuretic treatment can normalise endotoxin concentrations.