K
Kerstin Wolk
Researcher at Charité
Publications - 108
Citations - 11196
Kerstin Wolk is an academic researcher from Charité. The author has contributed to research in topics: Psoriasis & Cytokine. The author has an hindex of 43, co-authored 98 publications receiving 9960 citations. Previous affiliations of Kerstin Wolk include Humboldt University of Berlin & Schering AG.
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Journal ArticleDOI
IL-22 increases the innate immunity of tissues.
Kerstin Wolk,Stefanie Kunz,Ellen Witte,Markus Friedrich,Khusru Asadullah,Robert Sabat,Robert Sabat +6 more
TL;DR: IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues.
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IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes : a potential role in psoriasis
Kerstin Wolk,Ellen Witte,Elizabeth Wallace,Wolf-Dietrich Döcke,Stefanie Kunz,Khusru Asadullah,Hans-Dieter Volk,Wolfram Sterry,Robert Sabat +8 more
TL;DR: It is demonstrated that IL‐22, in contrast to its relative IFN‐γ, regulates the expression of only a few genes in keratinocytes, which may be important in the innate immunity and reorganization of epithelia.
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Biology of interleukin-10
Robert Sabat,Gerald Grütz,Katarzyna Warszawska,Stefan Kirsch,Ellen Witte,Kerstin Wolk,Jens Geginat +6 more
TL;DR: The special physiological relevance of this cytokine lies in the prevention and limitation of over-whelming specific and unspecific immune reactions and, in consequence, of tissue damage.
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Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?
TL;DR: Investigation of the expression of five novel human IL-10-related molecules and their receptors in blood mononuclear cells found IL-19 and IL-20 were found to be preferentially expressed in monocytes, and monocytes and NK, B, and T cells showed clear expression only of IL- 10R1,IL-10R2, andIL-20R2.
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Immunopathogenesis of psoriasis
Robert Sabat,Sandra Philipp,Conny Höflich,Stefanie Kreutzer,Elizabeth Wallace,Khusru Asadullah,Hans-Dieter Volk,Wolfram Sterry,Kerstin Wolk +8 more
TL;DR: It is postulated that the pathogenesis of psoriasis consists of distinct subsequent stages, in each of them different cell types playing a dominant role, which helps to explain the varied effectiveness of the currently tested immune modulating therapies and may enable the prediction of the success of future therapies.