K
Kiat Hoe Ong
Researcher at Tan Tock Seng Hospital
Publications - 37
Citations - 1218
Kiat Hoe Ong is an academic researcher from Tan Tock Seng Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 11, co-authored 28 publications receiving 892 citations. Previous affiliations of Kiat Hoe Ong include Khoo Teck Puat Hospital.
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Journal ArticleDOI
Hematologic parameters in patients with COVID-19 infection.
Bingwen Eugene Fan,Vanessa Cui Lian Chong,Stephrene Seok Wei Chan,Gek Hsiang Lim,Kian Guan Eric Lim,Guat Bee Tan,Sharavan Sadasiv Mucheli,Ponnudurai Kuperan,Kiat Hoe Ong +8 more
TL;DR: A detailed analysis of the hematological parameters of the COVID-19 patients at the NCID revealed that a higher number of patients (69%) who were lymphopenic had the presence of a few reactive lymphocytes, of which a subset appeared lymphoplasmacytoid, which contrasts with the severe acute respiratory syndrome (SARS) outbreak in 2003 where reactive lymph cells were not observed in a study on Haematologic parameters.
Journal ArticleDOI
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.
Stefan Hart,K C Goh,V Novotny-Diermayr,C Y Hu,Hannes Hentze,Y C Tan,Babita Madan,Chithra Amalini,Y.K. Loh,L C Ong,Anthony D. William,A Lee,Anders Poulsen,Ramesh Jayaraman,Kiat Hoe Ong,Kantharaj Ethirajulu,Brian Dymock,J W Wood +17 more
TL;DR: SB1518 has a unique profile and is efficacious and well tolerated in JAK2-dependent models, now being confirmed in clinical studies in patients with myelofibrosis and lymphoma.
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TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties
K C Goh,V Novotny-Diermayr,Stefan Hart,L C Ong,Y.K. Loh,Angela Cheong,Y C Tan,C Y Hu,Ramesh Jayaraman,Anthony D. William,E.T. Sun,Brian Dymock,Kiat Hoe Ong,Kantharaj Ethirajulu,F Burrows,J.M. Wood +15 more
TL;DR: TG02 induces tumor regression after oral dosing on both daily and intermittent schedules in a murine model of mutant-FLT3 leukemia and prolongs survival in a disseminated AML model with wild-type FLT3 and JAK2 (HL-60).
Journal ArticleDOI
COVID-19 and mycoplasma pneumoniae coinfection.
Bingwen Eugene Fan,Kian Guan Eric Lim,Vanessa Cui Lian Chong,Stephrene Seok Wei Chan,Kiat Hoe Ong,Ponnudurai Kuperan +5 more
TL;DR: COVID-19 and mycoplasma pneumoniae coinfection Bingwen Eugene Fan, Vanessa Cui Lian Chong, Stephrene Seok Wei Chan, and Ponnudurai Kuperan Department of Haematology and Singapore Department of Laboratory Medicine.
Journal ArticleDOI
Blood and blood product use during COVID-19 infection.
Bingwen Eugene Fan,Kiat Hoe Ong,Stephrene Seok Wei Chan,Barnaby Edward Young,Vanessa Cui Lian Chong,Siew Ping Connie Chen,Shu Ping Lim,Geok Ping Lim,Ponnudurai Kuperan +8 more
TL;DR: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China and Elevated activated partial thromboplastin time-based clot waveform analysis markers have strong positive association with acute venous thromboembolism.