Nicolas Bruder

TL;DR: Recommendations were developed based on literature review using the GRADE system, discussion integrating the literature with the collective experience of the participants and critical review by an impartial jury and emphasis was placed on the principle that recommendations should be based not only on the quality of the data but also tradeoffs and translation into practice.

TL;DR: The trial did not demonstrate any major benefit of tracheotomy in a general population of ICU patients, as suggested in a previous meta-analysis, but was underpowered to draw any firm conclusions.

TL;DR: The data suggest that in humans, unconsciousness mainly involves the cortical brain, but that suppression of movement in response to noxious stimuli is mediated through the effect of anesthetic agents on subcortical structures.

TL;DR: As compared to the continuation of the empirical antimicrobial treatment, a strategy based on de-escalation of antibiotics resulted in prolonged duration of ICU stay, however, it did not affect the mortality rate.

TL;DR: The use of TCD at hospital admission allows identification of severely brain-injured patients with brain hypoperfusion and can restore normal cerebral perfusion and might then potentially help in reducing the extent of secondary brain injury.