Gregory J. Zipfel

TL;DR: From a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies, intrinsic tissue mechanisms of ischaemic brain injury are discussed.

TL;DR: Recommendations were developed based on literature review using the GRADE system, discussion integrating the literature with the collective experience of the participants and critical review by an impartial jury and emphasis was placed on the principle that recommendations should be based not only on the quality of the data but also tradeoffs and translation into practice.

TL;DR: A summary of the meeting and the resultant discussion of how vascular factors contribute to Alzheimer's disease and related dementia is summarized, including an outline of next steps needed to move this area of research forward.

TL;DR: The role of injury-enhancing signaling mechanisms specific to the central nervous system (CNS) are emphasized and potential therapeutic approaches to interrupting these mechanisms are discussed.

TL;DR: Moyamoya phenomenon in North American adults is associated with a high risk of recurrent stroke, particularly those with bilateral involvement and ischemic symptoms, and data suggest a potential benefit with surgery if diagnosis could be made earlier.