P
Philip J. de Groot
Researcher at Wageningen University and Research Centre
Publications - 19
Citations - 1966
Philip J. de Groot is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Regulation of gene expression & Peroxisome proliferator-activated receptor. The author has an hindex of 16, co-authored 19 publications receiving 1836 citations. Previous affiliations of Philip J. de Groot include University of Amsterdam.
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Journal ArticleDOI
Differential NF-κB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance
Peter van Baarlen,Freddy J. Troost,Saskia van Hemert,Cindy van der Meer,Willem M. de Vos,Philip J. de Groot,Guido J. E. J. Hooiveld,Robert-Jan M. Brummer,Michiel Kleerebezem +8 more
TL;DR: This in vivo study identified mucosal gene expression patterns and cellular pathways that correlated with the establishment of immune tolerance in healthy adults that were identified in a randomized double-blind placebo-controlled cross-over study.
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Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling.
Maryam Rakhshandehroo,Linda M. Sanderson,Merja Matilainen,Rinke Stienstra,Carsten Carlberg,Philip J. de Groot,Michael Müller,Sander Kersten +7 more
TL;DR: In this paper, the power of transcriptional profiling to uncover novel PPARα-regulated genes and pathways in liver was illustrated, using an in silico screening approach, one or more PPAR response elements were identified in each of these genes.
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The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice
Nicole de Wit,Hanneke Bosch-Vermeulen,Philip J. de Groot,Guido J. E. J. Hooiveld,Mechteld Grootte Bromhaar,Jenny Jansen,Michael Müller,Roelof van der Meer +7 more
TL;DR: During dietary fat-induced development of obesity and insulin resistance, substantial changes in gene expression in the small intestine are found, indicating modulations of biological processes, especially related to lipid metabolism.
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MADMAX - Management and analysis database for multiple ~omics experiments
Ke Lin,Harrie J. Kools,Philip J. de Groot,Anand Gavai,Ram Kumar Basnet,Feng Cheng,Jian Wu,Xiaowu Wang,Arjen Lommen,Guido J. E. J. Hooiveld,Guusje Bonnema,Richard G. F. Visser,Michael Müller,Jack A. M. Leunissen +13 more
TL;DR: MADMAX is designed to provide a solution for storage and analysis of complex ~omics datasets and constitutes an ISA-Tab compliant LIMS part which is independent of different analysis pipelines.
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Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs
Wilma T. Steegenga,Mark V. Boekschoten,Carolien Lute,Guido J. E. J. Hooiveld,Philip J. de Groot,Tiffany Morris,Andrew E. Teschendorff,Lee M. Butcher,Stephan Beck,Michael Müller +9 more
TL;DR: Age-related differential methylation of previously reported epigenetic biomarkers of aging including ELOVL2, FHL2, PENK, and KLF14 was confirmed in this study, but these genes did not display an age-related change in gene expression in PBMCs.