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Yuzhang Wu
Researcher at Third Military Medical University
Publications - 296
Citations - 11030
Yuzhang Wu is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 40, co-authored 274 publications receiving 8126 citations. Previous affiliations of Yuzhang Wu include Chinese PLA General Hospital.
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Journal ArticleDOI
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19).
Bo Diao,Chenhui Wang,Yingjun Tan,Xiewan Chen,Ying Liu,Lifen Ning,Li Chen,Min Li,Yueping Liu,Gang Wang,Zilin Yuan,Zeqing Feng,Yi Zhang,Yuzhang Wu,Yongwen Chen +14 more
TL;DR: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted, and non-ICU patients with total T cells counts lower than 800/μL may still require urgent intervention, even in the immediate absence of more severe symptoms.
Posted ContentDOI
Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)
Bo Diao,Chenhui Wang,Yingjun Tan,Xiewan Chen,Ying Liu,Lifen Ning,Li Chen,Min Li,Yueping Liu,Gang Wang,Zilin Yuan,Zeqing Feng,Yuzhang Wu,Yongwen Chen +13 more
TL;DR: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted, with patients in decline period showing reduced IL-6, IL-10 and TNF-α concentrations and restored T cell counts.
Journal ArticleDOI
Follicular CXCR5-expressing CD8 + T cells curtail chronic viral infection
Ran He,Shiyue Hou,Cheng Liu,Anli Zhang,Qiang Bai,Miao Han,Yu Yang,Gang Wei,Ting Shen,Xinxin Yang,Lifan Xu,Xiangyu Chen,Yaxing Hao,Pengcheng Wang,Chuhong Zhu,Juanjuan Ou,Houjie Liang,Ting Ni,Xiaoyan Zhang,Xinyuan Zhou,Kai Deng,Yaokai Chen,Yadong Luo,Jianqing Xu,Hai Qi,Yuzhang Wu,Lilin Ye +26 more
TL;DR: A subset of exhausted CD8+ T cells expressing the chemokine receptor CXCR5 has a critical role in the control of viral replication in mice that were chronically infected with lymphocytic choriomeningitis virus (LCMV).
Posted ContentDOI
Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Bo Diao,Changzheng Wang,Rongshuai Wang,Zeqing Feng,Yingjun Tan,Hang Wang,Lei Liu,Yueping Liu,Gang Wang,Zilin Yuan,Li Ren,Yuzhang Wu,Chen Y +12 more
TL;DR: A retrospective analysis of estimated glomerular filtration rate (eGFR) along with other clinical parameters from 85 patients with laboratory-confirmed COVID-19 admitted to a hospital in Wuhan from January 17, 2020 to March 3, 2020 found that SARS-CoV-2 induces ARF in CO VID-19 patients.
Journal ArticleDOI
Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor.
Xiangyu Chen,Ren Li,Ren Li,Zhiwei Pan,Chunfang Qian,Yang Yang,Renrong You,Jing Zhao,Pinghuang Liu,Leiqiong Gao,Zhirong Li,Qizhao Huang,Lifan Xu,Jianfang Tang,Qin Tian,Wei Yao,Li Hu,Xiaofeng Yan,Xinyuan Zhou,Yuzhang Wu,Kai Deng,Zheng Zhang,Zhaohui Qian,Yaokai Chen,Lilin Ye +24 more
TL;DR: The aim was to identify and clone blocking mAbs from the memory B cell repertoire of recently recovered CO VID-19 patients to prevent the entry of COVID-19 virus to the host cells.