Barriers to drug delivery in solid tumors
TLDR
This review hopes to provide the reader with a clear understanding and knowledge of biological barriers and the methods to exploit these characteristics to design multifunctional nanocarriers, effect useful dosing regimens and subsequently improve therapeutic outcomes in the clinic.Abstract:
Over the last decade, significant progress has been made in the field of drug delivery. The advent of engineered nanoparticles has allowed us to circumvent the initial limitations to drug delivery ...read more
Citations
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On-Chip Preparation of Amphiphilic Nanomicelles-in-Sodium Alginate Spheroids as a Novel Platform Against Triple-Negative Human Breast Cancer Cells: Fabrication, Study of Microfluidics Flow Hydrodynamics and Proof of Concept for Anticancer and Drug Delivery Applications.
TL;DR: The designed nano-in-micro drug delivery system revealed a superior cytotoxicity against TNBC cell line (MDA-MB-231), besides, a more sustained release of the drug.
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Estimation of effective Poissons ratio in non-homogeneous porous media using two ultrasound transducers: A feasibility study
TL;DR: This paper investigates a new method to estimate EPR in non-homogeneous porous media using two linear array transducers and suggests that, using this new technique, it is feasible to estimate the temporal behavior of EPR with significantly higher image quality than previously possible.
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Drug penetration in pediatric brain tumors: Challenges and opportunities.
TL;DR: In this article, the authors expand on how systemic and local barriers limit drug penetration and present potential methods to enhance drug penetration in pediatric brain tumors, and design drug delivery systems to circumvent these barriers could lead to improved drug penetration at the tumor site and reduce adverse systemic side effects.
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In situ forming oxygen/ROS-responsive niche-like hydrogel enabling gelation-triggered chemotherapy and inhibition of metastasis
Shi-Xiong Chen,Ji Zhang,Fengfeng Xue,Wei Liu,Yichen Kuang,Bingxin Gu,Shaoli Song,Hangrong Chen +7 more
TL;DR: In this paper , a functional chitosan polymer (CS-FTP) is synthesized for construction of a hydrogel-based bio-niche in aiming at remodeling tumor hypoxic microenvironment.
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Microfluidic one-directional interstitial flow generation from cancer to cancer associated fibroblast.
TL;DR: In this article , a microfluidic device was designed to generate a one-directional flow of a small volume mimicking IF from donor cells to recipient at steady-state conditions only based on the medium evaporation from reservoirs with different diameter.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.
Tommy Cedervall,Iseult Lynch,Stina Lindman,Tord Berggård,Eva Thulin,Hanna Nilsson,Kenneth A. Dawson,Sara Linse +7 more
TL;DR: The rates of protein association and dissociation are determined using surface plasmon resonance technology with nanoparticles that are thiol-linked to gold, and through size exclusion chromatography of protein–nanoparticle mixtures, and this method is developed into a systematic methodology to isolate nanoparticle-associated proteins.
Journal ArticleDOI
Knocking down barriers: advances in siRNA delivery
TL;DR: An update on the progress of RNAi therapeutics is provided and novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids are highlighted.
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