E
Elizabeth Vincan
Researcher at University of Melbourne
Publications - 65
Citations - 3995
Elizabeth Vincan is an academic researcher from University of Melbourne. The author has contributed to research in topics: Wnt signaling pathway & Frizzled. The author has an hindex of 25, co-authored 52 publications receiving 3522 citations. Previous affiliations of Elizabeth Vincan include Royal Melbourne Hospital & Peter MacCallum Cancer Centre.
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Journal ArticleDOI
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
TL;DR: Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.
Journal Article
The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.
Amanda J. Philp,Ian G. Campbell,Christine S. F. Leet,Elizabeth Vincan,Steven Rockman,Robert H. Whitehead,Robert J. Thomas,Wayne A. Phillips +7 more
TL;DR: expression of a mutant protein with a 23 amino acid deletion leads to constitutive activation of PI3k providing the first direct evidence that p85alpha is a new oncogene involved in human tumorigenesis.
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The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression.
Elizabeth Vincan,Nick Barker +1 more
TL;DR: The constitutive activation of beta-catenin-dependent Wnt signalling is a necessary initiating event in the genesis of most colorectal cancers as discussed by the authors, and many of the genes associated with tumour invasion and metastasis are transcriptional target genes that are dynamically regulated during cancer progression.
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Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma.
Steven Rockman,Scott A. Currie,Marianne L. Ciavarella,Elizabeth Vincan,Chris Dow,Robert J. Thomas,Wayne A. Phillips +6 more
TL;DR: It is reported that the dominant negative helix-loop-helix regulator Id2 is also a target of the β-catenin/TCF transcription pathway in colon adenocarcinoma and the findings suggest that this dysregulation of Id2 expression is due to the activation of theβ- catenin-TCF pathway.
Journal ArticleDOI
Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells
Dustin J. Flanagan,Toby J. Phesse,Nick Barker,Renate H.M. Schwab,Nancy Amin,Jordane Malaterre,Daniel E. Stange,Cameron J. Nowell,Scott A. Currie,Jarel T.S. Saw,Eva Beuchert,Robert G. Ramsay,Owen J. Sansom,Matthias Ernst,Hans Clevers,Elizabeth Vincan,Elizabeth Vincan +16 more
TL;DR: Observations indicate that Fzd7 is required for robust Wnt-dependent processes in Lgr5+ intestinal stem cells, and binds Wnt3 and Wnt2b.