O
Otto Schmalhofer
Researcher at University of Freiburg
Publications - 12
Citations - 6299
Otto Schmalhofer is an academic researcher from University of Freiburg. The author has contributed to research in topics: Epithelial–mesenchymal transition & Metastasis. The author has an hindex of 10, co-authored 12 publications receiving 5763 citations. Previous affiliations of Otto Schmalhofer include University of Erlangen-Nuremberg.
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Journal ArticleDOI
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
TL;DR: Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.
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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Ulrich F. Wellner,Jörg Schubert,Ulrike Burk,Otto Schmalhofer,Feng Zhu,Annika G Sonntag,Bettina Waldvogel,Corinne Vannier,Douglas S. Darling,Axel zur Hausen,Valerie G. Brunton,Jennifer P. Morton,Owen J. Sansom,Julia Schüler,Marc P. Stemmler,Christoph Herzberger,Ulrich T. Hopt,Tobias Keck,Simone Brabletz,Thomas Brabletz +19 more
TL;DR: It is proposed that ZEB1 links EMT-activation and stemness-maintenance by suppressingstemness-inhibiting microRNAs (miRNAs) and thereby is a promoter of mobile, migrating cancer stem cells.
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E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer.
TL;DR: Mounting evidence indicates multiple reciprocal interactions of E-cadherin and β-catenin with EMT-inducing transcriptional repressors to stabilize an invasive mesenchymal phenotype of epithelial tumor cells.
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The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
Angela M. Krebs,Julia Mitschke,María Lasierra Losada,Otto Schmalhofer,Melanie Boerries,Melanie Boerries,Hauke Busch,Hauke Busch,Martin Boettcher,Dimitrios Mougiakakos,Wilfried Reichardt,Wilfried Reichardt,Peter Bronsert,Peter Bronsert,Valerie G. Brunton,Christian Pilarsky,Thomas Winkler,Simone Brabletz,Marc P. Stemmler,Thomas Brabletz +19 more
TL;DR: It is shown that different EMT-TFs have complementary subfunctions in driving pancreatic tumour metastasis, and that Depletion of Zeb1 suppresses stemness, colonization capacity and in particular phenotypic/metabolic plasticity of tumour cells, probably causing the observed in vivo effects.
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Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
Thomas Brabletz,Falk Hlubek,Simone Spaderna,Otto Schmalhofer,Elke Hiendlmeyer,Andreas Jung,Thomas Kirchner +6 more
TL;DR: Accumulating data demonstrate that aberrant nuclear expression of β-catenin can also confer two fundamental processes in embryonic development: EMT and stem cell formation, thereby driving malignant tumor progression.