U
Ulrich F. Wellner
Researcher at University of Lübeck
Publications - 181
Citations - 8675
Ulrich F. Wellner is an academic researcher from University of Lübeck. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 34, co-authored 168 publications receiving 7260 citations. Previous affiliations of Ulrich F. Wellner include University Medical Center Freiburg & University of Freiburg.
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Journal ArticleDOI
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
TL;DR: Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.
Journal ArticleDOI
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Ulrich F. Wellner,Jörg Schubert,Ulrike Burk,Otto Schmalhofer,Feng Zhu,Annika G Sonntag,Bettina Waldvogel,Corinne Vannier,Douglas S. Darling,Axel zur Hausen,Valerie G. Brunton,Jennifer P. Morton,Owen J. Sansom,Julia Schüler,Marc P. Stemmler,Christoph Herzberger,Ulrich T. Hopt,Tobias Keck,Simone Brabletz,Thomas Brabletz +19 more
TL;DR: It is proposed that ZEB1 links EMT-activation and stemness-maintenance by suppressingstemness-inhibiting microRNAs (miRNAs) and thereby is a promoter of mobile, migrating cancer stem cells.
Journal ArticleDOI
The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.
Simone Brabletz,Karolina Bajdak,Simone Meidhof,Ulrike Burk,Gabriele Niedermann,Elke Firat,Ulrich F. Wellner,Arno Dimmler,Gerhard Faller,Jörg Schubert,Thomas Brabletz +10 more
TL;DR: It is shown that miR‐200 members target Notch pathway components, such as Jagged1 (Jag1) and the mastermind‐like coactivators Maml2 and Maml3, thereby mediating enhanced Notch activation by ZEB1, which explains increased Notch signalling in some types of cancers.
Journal ArticleDOI
Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
Matteo Ligorio,Srinjoy Sil,Jose Malagon-Lopez,Linda T. Nieman,Sandra Misale,Mauro Di Pilato,Richard Y. Ebright,Murat Karabacak,Anupriya S. Kulkarni,A. W. K. Liu,Nicole Vincent Jordan,Joseph W. Franses,Julia Philipp,Johannes Kreuzer,Niyati Desai,Kshitij S. Arora,Mihir Rajurkar,Elad Horwitz,Azfar Neyaz,Eric Tai,Neelima K.C. Magnus,Kevin D. Vo,Chittampalli Yashaswini,Francesco Marangoni,Myriam Boukhali,Jackson P. Fatherree,Leah J. Damon,Kristina Xega,Rushil Desai,Melissa Choz,Francesca Bersani,Adam Langenbucher,Vishal Thapar,Robert Morris,Ulrich F. Wellner,Oliver Schilling,Michael S. Lawrence,Andrew S. Liss,Miguel Rivera,Vikram Deshpande,Cyril H. Benes,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Carlos Fernandez-del-Castillo,Cristina R. Ferrone,Wilhelm Haas,Martin J. Aryee,David T. Ting +48 more
TL;DR: The impact of the stroma is demonstrated in shaping tumor architecture by altering inherent patterns of tumor glands in human PDAC by quantifying EMT and PRO subpopulations in 319,626 individual cancer cells that can be classified within the context of distinct tumor gland "units".
Journal ArticleDOI
The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer
Hartwig Riediger,Tobias Keck,Ulrich F. Wellner,Axel zur Hausen,Ulrich Adam,Ulrich T. Hopt,Frank Makowiec +6 more
TL;DR: The routine estimation of the LN ratio may be helpful not only for the individual prediction of prognosis but also for the indication of adjuvant therapy and herein related outcome and therapy studies.