S
Simone Spaderna
Researcher at University of Erlangen-Nuremberg
Publications - 18
Citations - 5077
Simone Spaderna is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 16, co-authored 18 publications receiving 4795 citations. Previous affiliations of Simone Spaderna include University of Freiburg.
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Journal ArticleDOI
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
TL;DR: Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.
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Migrating cancer stem cells — an integrated concept of malignant tumour progression
TL;DR: An extended, integrated model that is consistent with all aspects of human tumour progression is suggested — the 'migrating cancer stem (MCS)-cell' concept.
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Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
Thomas Brabletz,Falk Hlubek,Simone Spaderna,Otto Schmalhofer,Elke Hiendlmeyer,Andreas Jung,Thomas Kirchner +6 more
TL;DR: Accumulating data demonstrate that aberrant nuclear expression of β-catenin can also confer two fundamental processes in embryonic development: EMT and stem cell formation, thereby driving malignant tumor progression.
Journal ArticleDOI
The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer
Simone Spaderna,Otto Schmalhofer,Mandy Wahlbuhl,Arno Dimmler,Katja Bauer,Aneesa Sultan,Falk Hlubek,Andreas Jung,Dennis Strand,Andreas Eger,Thomas Kirchner,Jürgen Behrens,Thomas Brabletz +12 more
TL;DR: It is described that the EMT-inducing transcriptional repressor ZEB1 promotes colorectal cancer cell metastasis and loss of cell polarity and shows that retention of Lgl2 expression is critical for the epithelial phenotype and that its loss might be involved in metastasis.
Journal ArticleDOI
A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.
Simone Spaderna,Otto Schmalhofer,Falk Hlubek,Geert Berx,Andreas Eger,Susanne Merkel,Andreas Jung,Thomas Kirchner,Thomas Brabletz +8 more
TL;DR: A transient BM loss at the invasive front is correlated with increased distant metastasis and poor patient survival, indicating its tumor biologic relevance and usefulness as a prognostic marker.