H
Helge Karch
Researcher at University of Münster
Publications - 369
Citations - 27622
Helge Karch is an academic researcher from University of Münster. The author has contributed to research in topics: Escherichia coli & Shiga toxin. The author has an hindex of 85, co-authored 369 publications receiving 26212 citations. Previous affiliations of Helge Karch include University of Würzburg.
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Journal ArticleDOI
Sex and virulence in Escherichia coli: an evolutionary perspective
Thierry Wirth,Daniel Falush,Ruiting Lan,Frances M. Colles,Patience Mensa,Lothar H. Wieler,Helge Karch,Peter R. Reeves,Martin C. J. Maiden,Howard Ochman,Mark Achtman +10 more
TL;DR: The evolution of virulence is linked to bacterial sex because rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination.
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Molecular analysis of the plasmid-encoded hemolysin of Escherichia coli O157:H7 strain EDL 933.
TL;DR: The newly discovered EHEC hemolysin was shown to be responsible for the enterohemolytic phenotype and demonstrated to be related but not identical to alpha-hemolysin.
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Prospective Genomic Characterization of the German Enterohemorrhagic Escherichia coli O104:H4 Outbreak by Rapid Next Generation Sequencing Technology
Alexander Mellmann,Dag Harmsen,Craig Cummings,Emily B. Zentz,Shana R. Leopold,Alain Rico,Karola Prior,Rafael Szczepanowski,Yongmei Ji,Wenlan Zhang,Stephen F. McLaughlin,John K. Henkhaus,Benjamin Leopold,Martina Bielaszewska,Rita Prager,Pius Brzoska,Richard Moore,Simone Guenther,Jonathan M. Rothberg,Helge Karch +19 more
TL;DR: It is suggested that by stepwise gain and loss of chromosomal and plasmid-encoded virulence factors, a highly pathogenic hybrid of EAEC and EHEC emerged as the current outbreak clone.
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Escherichia coli Harboring Shiga Toxin 2 Gene Variants: Frequency and Association with Clinical Symptoms
Alexander W. Friedrich,Martina Bielaszewska,Wenlan Zhang,Matthias Pulz,Thorsten Kuczius,Andrea Ammon,Helge Karch +6 more
TL;DR: Stx2c-positive STEC isolates can cause HUS, but the presence of stx2d or stX2e may predict a milder disease with a minimal risk of HUS.
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Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study
Martina Bielaszewska,Alexander Mellmann,Wenlan Zhang,Robin Köck,Angelika Fruth,Andreas Bauwens,Georg Peters,Helge Karch +7 more
TL;DR: Augmented adherence of the strain to intestinal epithelium might facilitate systemic absorption of Shiga toxin and could explain the high progression to haemolytic uraemic syndrome.