L
Lothar H. Wieler
Researcher at Robert Koch Institute
Publications - 272
Citations - 17664
Lothar H. Wieler is an academic researcher from Robert Koch Institute. The author has contributed to research in topics: Escherichia coli & Virulence. The author has an hindex of 62, co-authored 238 publications receiving 15200 citations. Previous affiliations of Lothar H. Wieler include Free University of Berlin & University of Giessen.
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Journal ArticleDOI
Sex and virulence in Escherichia coli: an evolutionary perspective
Thierry Wirth,Daniel Falush,Ruiting Lan,Frances M. Colles,Patience Mensa,Lothar H. Wieler,Helge Karch,Peter R. Reeves,Martin C. J. Maiden,Howard Ochman,Mark Achtman +10 more
TL;DR: The evolution of virulence is linked to bacterial sex because rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination.
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COVID-19: towards controlling of a pandemic.
Juliet Bedford,Delia Enria,Johan Giesecke,David L Heymann,Chikwe Ihekweazu,Gary P. Kobinger,H. Clifford Lane,Ziad A. Memish,Myoung Don Oh,Amadou A. Sall,Anne Schuchat,Kumnuan Ungchusak,Lothar H. Wieler +12 more
TL;DR: In this paper, the authors proposed a method to solve the problem of homonymity in the context of cancer diagnosis.http://www.thelancet.com Vol 395 March 28, 202
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Extended-spectrum β-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective
TL;DR: The opinion that animal ESBL-producing E. coli is a major source of human infections is oversimplified, and neglects a highly complex scenario.
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Avian pathogenic, uropathogenic, and newborn meningitis-causing Escherichia coli: How closely related are they?
Christa Ewers,Ganwu Li,Hendrik Wilking,Sabine Kiessling,Katja Alt,Esther-Maria Antão,Claudia Laturnus,Ines Diehl,Susanne Glodde,Timo Homeier,Ute Böhnke,H. Steinrück,Hans-C Philipp,Lothar H. Wieler +13 more
TL;DR: The hypothesis that poultry may be a vehicle or even a reservoir for human ExPEC strains and APEC potentially serve as a reservoir of virulence-associated genes for UPEC and NMEC is supported, and some ExPec strains, although of different pathotypes, may share common ancestors, and as a conclusion certain APEC subgroups have to be considered potential zoonotic agents.
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Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine
Peter Schierack,Marcel Nordhoff,Marion Pollmann,Karl Dietrich Weyrauch,Salah Amasheh,Ulrike Lodemann,Jörg Jores,Babila Tachu,Sylvia Kleta,Anthony T. Blikslager,Karsten Tedin,Lothar H. Wieler +11 more
TL;DR: The permanent porcine intestinal epithelial cell line, IPEC-J2, is characterized using a variety of methods to assess the usefulness of this cell line as an in vitro infection model and concludes that it provides a relevant in vitro model system for porCine intestinal pathogen–host cell interactions.