M
Mark Achtman
Researcher at University of Warwick
Publications - 248
Citations - 33255
Mark Achtman is an academic researcher from University of Warwick. The author has contributed to research in topics: Neisseria meningitidis & Population. The author has an hindex of 89, co-authored 246 publications receiving 30746 citations. Previous affiliations of Mark Achtman include University College Cork & University of Khartoum.
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Journal ArticleDOI
Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms
Martin C. J. Maiden,Jane A. Bygraves,Edward J. Feil,Giovanna Morelli,Joanne E. Russell,Rachel Urwin,Qing Zhang,Jiaji Zhou,Kerstin Zurth,Dominique A. Caugant,Ian M. Feavers,Mark Achtman,Brian G. Spratt +12 more
TL;DR: Multilocus sequence typing (MLST), which exploits the unambiguous nature and electronic portability of nucleotide sequence data for the characterization of microorganisms, can be applied to almost all bacterial species and other haploid organisms, including those that are difficult to cultivate.
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Sex and virulence in Escherichia coli: an evolutionary perspective
Thierry Wirth,Daniel Falush,Ruiting Lan,Frances M. Colles,Patience Mensa,Lothar H. Wieler,Helge Karch,Peter R. Reeves,Martin C. J. Maiden,Howard Ochman,Mark Achtman +10 more
TL;DR: The evolution of virulence is linked to bacterial sex because rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination.
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Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
TL;DR: Analysis of the population genetic structure of Y. pestis and the two other pathogenic Yersinia species shows consistent with previous inferences that Antiqua caused a plague pandemic in the sixth century, Medievalis caused the Black Death and subsequent epidemics during the second pandemic wave, and Orientalis cause the current Plague pandemic.
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Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
Julian Parkhill,Mohammed Sebaihia,Andrew Preston,Lee Murphy,Nicholas R. Thomson,David Harris,Matthew T. G. Holden,Carol Churcher,Stephen D. Bentley,Karen Mungall,Ana Cerdeño-Tárraga,Louise M. Temple,Keith D. James,Barbara Harris,Michael A. Quail,Mark Achtman,Rebecca Atkin,Steven K. Baker,David Basham,Nathalie Bason,Inna Cherevach,Tracey Chillingworth,Matthew Collins,Anne Cronin,Paul Davis,Jonathan Doggett,Theresa Feltwell,Arlette Goble,N. Hamlin,Heidi Hauser,S. Holroyd,Kay Jagels,Sampsa Leather,Sharon Moule,Halina Norberczak,Susan O'Neil,Doug Ormond,Claire Price,Ester Rabbinowitsch,Simon Rutter,Mandy Sanders,David L. Saunders,Katherine Seeger,Sarah Sharp,Mark Simmonds,Jason Skelton,R. Squares,S. Squares,K. Stevens,Louise Unwin,Sally Whitehead,Bart Barrell,Duncan J. Maskell +52 more
TL;DR: The authors' analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.
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Traces of human migrations in Helicobacter pylori populations
Daniel Falush,Thierry Wirth,Bodo Linz,Jonathan K. Pritchard,Matthew Stephens,Mark Kidd,Martin J. Blaser,David Y. Graham,Sylvie Vacher,Guillermo I. Perez-Perez,Yoshio Yamaoka,Francis Mégraud,Kristina Otto,Ulrike Reichard,Elena Katzowitsch,Xiaoyan Wang,Mark Achtman,Sebastian Suerbaum +17 more
TL;DR: Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions.