T
Thierry Wirth
Researcher at École pratique des hautes études
Publications - 62
Citations - 8386
Thierry Wirth is an academic researcher from École pratique des hautes études. The author has contributed to research in topics: Population & Lineage (genetic). The author has an hindex of 32, co-authored 59 publications receiving 7643 citations. Previous affiliations of Thierry Wirth include University of Konstanz & Centre national de la recherche scientifique.
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Journal ArticleDOI
Sex and virulence in Escherichia coli: an evolutionary perspective
Thierry Wirth,Daniel Falush,Ruiting Lan,Frances M. Colles,Patience Mensa,Lothar H. Wieler,Helge Karch,Peter R. Reeves,Martin C. J. Maiden,Howard Ochman,Mark Achtman +10 more
TL;DR: The evolution of virulence is linked to bacterial sex because rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination.
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Traces of human migrations in Helicobacter pylori populations
Daniel Falush,Thierry Wirth,Bodo Linz,Jonathan K. Pritchard,Matthew Stephens,Mark Kidd,Martin J. Blaser,David Y. Graham,Sylvie Vacher,Guillermo I. Perez-Perez,Yoshio Yamaoka,Francis Mégraud,Kristina Otto,Ulrike Reichard,Elena Katzowitsch,Xiaoyan Wang,Mark Achtman,Sebastian Suerbaum +17 more
TL;DR: Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions.
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A New Perspective on Listeria monocytogenes Evolution
Marie Ragon,Thierry Wirth,Florian Hollandt,Rachel Lavenir,Marc Lecuit,Alban Le Monnier,Alban Le Monnier,Sylvain Brisse +7 more
TL;DR: This work provides a reference evolutionary framework for future studies on L. monocytogenes epidemiology, ecology, and virulence, with convergent evolution indicative of natural selection towards a truncation of InlA protein.
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Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
Giovanna Morelli,Yajun Song,Yajun Song,Camila J. Mazzoni,Mark Eppinger,Philippe Roumagnac,David M. Wagner,Mirjam Feldkamp,Barica Kusecek,Amy J. Vogler,Yanjun Li,Yujun Cui,Nicholas R. Thomson,Thibaut Jombart,Raphaël Leblois,Peter Lichtner,Lila Rahalison,Jeannine M. Petersen,Francois Balloux,Paul Keim,Paul Keim,Thierry Wirth,Jacques Ravel,Ruifu Yang,Elisabeth Carniel,Mark Achtman +25 more
TL;DR: The phylogenetic analysis suggests that Y. pestis evolved in or near China and spread through multiple radiations to Europe, South America, Africa and Southeast Asia, leading to country-specific lineages that can be traced by lineage-specific SNPs.
Journal ArticleDOI
Microevolution and history of the plague bacillus, Yersinia pestis
Mark Achtman,Giovanna Morelli,Peixuan Zhu,Thierry Wirth,Ines Diehl,Barica Kusecek,Amy J. Vogler,David M. Wagner,Christopher J. Allender,W. Ryan Easterday,Viviane Chenal-Francisque,Patricia L. Worsham,Nicholas R. Thomson,Julian Parkhill,Luther E. Lindler,Elisabeth Carniel,Paul Keim +16 more
TL;DR: An evolutionary tree is proposed for these populations, rooted on Yersinia pseudotuberculosis, which invokes microevolution over millennia, during which enzootic pestoides isolates evolved and led to populations that are more frequently associated with human disease.