R
Ruiting Lan
Researcher at University of New South Wales
Publications - 218
Citations - 9927
Ruiting Lan is an academic researcher from University of New South Wales. The author has contributed to research in topics: Bordetella pertussis & Gene. The author has an hindex of 43, co-authored 205 publications receiving 8647 citations. Previous affiliations of Ruiting Lan include University of Sydney.
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Journal ArticleDOI
Sex and virulence in Escherichia coli: an evolutionary perspective
Thierry Wirth,Daniel Falush,Ruiting Lan,Frances M. Colles,Patience Mensa,Lothar H. Wieler,Helge Karch,Peter R. Reeves,Martin C. J. Maiden,Howard Ochman,Mark Achtman +10 more
TL;DR: The evolution of virulence is linked to bacterial sex because rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination.
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Multiple independent origins of Shigella clones of Escherichia coli and convergent evolution of many of their characteristics
TL;DR: The three main Shigella clusters are estimated to have evolved within the last 35,000 to 270,000 years, suggesting that shigellosis was one of the early infectious diseases of humans.
Journal ArticleDOI
Evolutionary Relationships among Pathogenic and Nonpathogenic Escherichia coli Strains Inferred from Multilocus Enzyme Electrophoresis and mdh Sequence Studies
TL;DR: The results suggest the possibility that any E. coli strain acquiring the appropriate virulence factors may give rise to a pathogenic form, and that the genus Shigella is shown to comprise a group of closely related pathogenic E. Escherichia coli strains.
Journal ArticleDOI
Intraspecies variation in bacterial genomes: the need for a species genome concept.
Ruiting Lan,Peter R. Reeves +1 more
TL;DR: The bacterial genome is a dynamic structure and intraspecies variation needs to be included in genome analysis if the authors are to gain insight into the full species genome.
Journal ArticleDOI
Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination
Marieke J. Bart,Simon R. Harris,Abdolreza Advani,Yoshichika Arakawa,Daniela Bottero,Valérie Bouchez,Valérie Bouchez,Pamela K. Cassiday,Chuen Sheue Chiang,Tine Dalby,Norman K. Fry,María Emilia Gaillard,Marjolein van Gent,Nicole Guiso,Nicole Guiso,Hans O. Hallander,Eric T. Harvill,Qiushui He,Han G. J. van der Heide,Kees Heuvelman,Daniela Flavia Hozbor,Kazunari Kamachi,Gennady I. Karataev,Ruiting Lan,Anna Lutyńska,Ram P. Maharjan,Jussi Mertsola,Tatsuo Miyamura,Sophie Octavia,Andrew Preston,Michael A. Quail,Vitali Sintchenko,Vitali Sintchenko,Paola Stefanelli,M. Lucia Tondella,Raymond S. W. Tsang,Yinghua Xu,Shu-Man Yao,Shumin Zhang,Julian Parkhill,Frits R. Mooi +40 more
TL;DR: In this paper, the authors applied comparative genomics to a worldwide collection of 343 B. pertussis isolates from around the world over the last 100 years and found that the organism has emerged within the last 500 years, consistent with historical records.