Jens Fiehler

TL;DR: In patients with acute stroke with an unknown time of onset, intravenous alteplase guided by a mismatch between diffusion‐weighted imaging and FLAIR in the region of ischemia resulted in a significantly better functional outcome and numerically more intracranial hemorrhages than placebo at 90 days.

TL;DR: In this article, a mismatch in visibility of acute ischaemic lesion between diffusion-weighted MRI (DWI) and fluid-attenuated inversion recovery (FLAIR) MRI was used to detect patients within the recommended time window for thrombolysis.

TL;DR: The original version of this consensus statement on mechanical thrombectomy was approved at the European Stroke Organisation-Karolinska Stroke Update conference in Stockholm, 16–18 November 2014 and has later, during 2015, been updated with new clinical trials data in accordance with a decision made at the conference.

TL;DR: Nerinetide did not improve the proportion of patients achieving good clinical outcomes after endovascular thrombectomy compared with patients receiving placebo, and this trial is registered with ClinicalTrials.gov, NCT02930018.

TL;DR: High quality evidence to recommend MT plus best medical management (BMM, including intravenous thrombolysis whenever indicated) to improve functional outcome in patients with LVO-related acute ischaemic stroke within 6 hours after symptom onset is found.