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Georg Auburger

Researcher at Goethe University Frankfurt

Publications -  230
Citations -  26230

Georg Auburger is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Spinocerebellar ataxia & Neurodegeneration. The author has an hindex of 61, co-authored 223 publications receiving 23982 citations. Previous affiliations of Georg Auburger include University of Düsseldorf & National Institutes of Health.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Eriza Maria Valente, +21 more
- 21 May 2004 - 
TL;DR: The identification of two homozygous mutations affecting the PINK1 kinase domain in three consanguineous PARK6 families provide a direct molecular link between mitochondria and the pathogenesis of PD.
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The ubiquitin pathway in Parkinson's disease

Elisabeth Leroy, +15 more
- 01 Oct 1998 - 
TL;DR: It is shown that in a German family with Parkinson's disease a missense mutation in the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene causes a partial loss of the catalytic activity of this thiol protease, which could lead to aberrations in the proteolytic pathway and aggregation of proteins.
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OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28.

Christiane Alexander, +12 more
- 01 Oct 2000 - 
TL;DR: The presence of consensus signal peptide sequences suggests that the product of the gene OPA1 is targeted to mitochondria and may exert its function in mitochondrial biogenesis and stabilization of mitochondrial membrane integrity.
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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

Andrew Elden, +22 more
- 26 Aug 2010 - 
TL;DR: It is shown that ataxin 2 (ATXN2), a polyglutamine (polyQ) protein mutated in spinocerebellar ataxia type 2, is a potent modifier of TDP-43 toxicity in animal and cellular models.