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Konstanze F. Winklhofer

Researcher at Ruhr University Bochum

Publications -  116
Citations -  14029

Konstanze F. Winklhofer is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Parkin & Mitochondrion. The author has an hindex of 47, co-authored 103 publications receiving 12503 citations. Previous affiliations of Konstanze F. Winklhofer include Free University of Berlin & German Center for Neurodegenerative Diseases.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Mitochondrial dysfunction in Parkinson's disease

Konstanze F. Winklhofer, +1 more
- 01 Jan 2010 - 
TL;DR: Recent research indicated that several PD-associated genes interface with pathways regulating mitochondrial function, morphology, and dynamics, and in fact, sporadic and familial PD seem to converge at the level of mitochondrial integrity.
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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

Nicole Exner, +3 more
- 18 Jul 2012 - 
TL;DR: The role of mitochondria in the etiopathogenesis of Parkinson's disease has been investigated in this paper, based on the observation that mitochondrial toxins can cause parkinsonism in humans and animal models.
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Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

Nicole Exner, +17 more
- 07 Nov 2007 - 
TL;DR: The results may suggest that PINK1 deficiency in humans results in mitochondrial abnormalities associated with cellular stress, a pathological phenotype, which can be ameliorated by enhanced expression of parkin.
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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

Frits Kamp, +18 more
- 20 Oct 2010 - 
TL;DR: It is demonstrated with in vitro vesicle fusion experiments that αS has an inhibitory function on membrane fusion and mitochondrial fragmentation induced by expression of αS is rescued by coexpression of PINK1, parkin or DJ‐1 but not the PD‐associated mutations Pink1 G309D and parkin Δ1–79 or byDJ‐1 C106A.