Maya Mills

TL;DR: These novel transgenic lines greatly expand the ability to monitor and manipulate neuronal activities with increased specificity, and develop driver and double reporter mouse lines and viral vectors using the Cre/Flp and Cre/Dre double recombinase systems.

TL;DR: A large set of driver and reporter transgenic mouse lines are reported, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools.

TL;DR: A high-throughput in situ hybridization (ISH), imaging and data processing pipeline to describe whole brain gene expression patterns in Cre driver mice is established and publicly available via the Allen Institute's Transgenic Characterization database.

TL;DR: A large set of driver and reporter transgenic mouse lines are reported, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools that enable optical physiology, optogenetics, and sparse labeling of genetically-defined cell populations.

TL;DR: TIGRE2.0 as mentioned in this paper introduces Cre-dependent reporter lines that enable optical physiology, optogenetics, and sparse labeling of genetically-defined cell populations, which greatly expands the repertoire of highprecision genetic tools available to effectively identify, monitor, and manipulate distinct cell types in the mouse brain.