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Nirmala Iyer
Researcher at Howard Hughes Medical Institute
Publications - 14
Citations - 2921
Nirmala Iyer is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Mushroom bodies & Associative learning. The author has an hindex of 7, co-authored 12 publications receiving 2122 citations.
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Journal ArticleDOI
A GAL4-Driver Line Resource for Drosophila Neurobiology
Arnim Jenett,Gerald M. Rubin,Teri-T B. Ngo,David Shepherd,Christine Murphy,Heather Dionne,Barret D. Pfeiffer,Amanda Cavallaro,Donald Hall,Jennifer Jeter,Nirmala Iyer,Dona Fetter,Joanna H. Hausenfluck,Hanchuan Peng,Eric T. Trautman,Robert Svirskas,Eugene W. Myers,Zbigniew R. Iwinski,Yoshinori Aso,Gina M. DePasquale,Adrianne Enos,Phuson Hulamm,S. Lam,Hsing-Hsi Li,Todd R. Laverty,Fuhui Long,Lei Qu,Sean D. Murphy,Konrad Rokicki,Todd Safford,Kshiti Shaw,Julie H. Simpson,Allison Sowell,Susana Tae,Yang Yu,Christopher T. Zugates +35 more
TL;DR: The utility of 7,000 transgenic lines of Drosophila melanogaster for identifying novel neuronal cell types, revealing brain asymmetry, and describing the nature and extent of neuronal shape stereotypy is illustrated.
Journal ArticleDOI
The neuronal architecture of the mushroom body provides a logic for associative learning
Yoshinori Aso,Daisuke Hattori,Yang Yu,Rebecca M. Johnston,Nirmala Iyer,Teri T.B. Ngo,Heather Dionne,Larry F. Abbott,Richard Axel,Hiromu Tanimoto,Gerald M. Rubin +10 more
TL;DR: The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.
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Neuroarchitecture and neuroanatomy of the Drosophila central complex: A GAL4-based dissection of protocerebral bridge neurons and circuits.
TL;DR: An updated map of the Drosophila central complex will facilitate a deeper behavioral and physiological dissection of this sophisticated set of structures and provides new insights into the anatomical structure of the four components of the central complex and its accessory neuropils.
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Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells
David P. Hoffman,Gleb Shtengel,C. Shan Xu,Kirby R. Campbell,Melanie Freeman,Lei Wang,Lei Wang,Daniel E. Milkie,H. Amalia Pasolli,Nirmala Iyer,John A. Bogovic,Daniel R. Stabley,Abbas Shirinifard,Song Pang,David Peale,Kathy Schaefer,Wim Pomp,Wim Pomp,Chi-Lun Chang,Jennifer Lippincott-Schwartz,Tom Kirchhausen,David J. Solecki,Eric Betzig,Harald F. Hess +23 more
TL;DR: A pipeline to preserve fluorescently labeled, cultured mammalian cells in vitreous ice and serve as a powerful hypothesis generator to better understand the findings of biochemistry in the context of the spatially compartmentalized cell.
Journal ArticleDOI
ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER.
Aubrey V. Weigel,Chi-Lun Chang,Gleb Shtengel,C. Shan Xu,David P. Hoffman,Melanie Freeman,Melanie Freeman,Nirmala Iyer,Jesse Aaron,Satya Khuon,John A. Bogovic,Wei Qiu,Harald F. Hess,Jennifer Lippincott-Schwartz +13 more
TL;DR: In this article, a 3D view of early secretory compartments in mammalian cells with isotropic resolution and precise protein localization using whole-cell, focused ion beam scanning electron microscopy with cryo-structured illumination microscopy and live-cell synchronized cargo release approaches is provided.