Irfan Rahman

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The spectrophotometric/microplate reader assay method for glutathione (GSH) can assay GSH in whole blood, plasma, serum, lung lavage fluid, cerebrospinal fluid, urine, tissues and cell extracts and can be extended for drug discovery/pharmacology and toxicology protocols to study the effects of drugs and toxic compounds on glutATHione metabolism.

TL;DR: The recent data suggest that dietary polyphenols can work as modifiers of signal transduction pathways to elicit their beneficial effects during oxidative stress, their metabolism and bioavailability.

TL;DR: The redox control and involvement of nuclear factor-kappaB and activator protein-1 in the regulation of cellular glutathione and gamma-glutamylcysteine synthetase under conditions of oxidative stress and inflammation are described.

TL;DR: Oxidative stress regulates both key signal transduction pathways and histone modifications involved in lung inflammation, and various approaches to enhance lung antioxidant capacity and clinical trials of antioxidant compounds in chronic obstructive pulmonary disease are discussed.