Alessandro Brero

TL;DR: It is concluded that nuclear functions in the studied cell types may not require reproducible side-by-side arrangements of specific homologous or non-homologous CTs, and that presently unknown factors may play a decisive role to enforce the different radial arrangements of large and small CTs observed in ellipsoid and spherical human cell nuclei.

TL;DR: It is shown that pericentric heterochromatin aggregates during myogenic differentiation, causing a dose-dependent clustering of chromocenters in the absence of differentiation, and this MeCP2- and MBD2-mediated chromatin reorganization may represent a molecular link between nuclear genome topology and the epigenetic maintenance of cellular differentiation.

TL;DR: Chromosome territory arrangements according to chromosome size and gene density provide common, evolutionary conserved themes in both, human and mouse cell types.

TL;DR: The location of centromeres and telomeres was studied in human and mouse lymphocyte nuclei employing 3D-FISH, confocal microscopy, and quantitative image analysis and found a peripheral location of both centromres and CTs for 1, 11, 12, 18, X.

TL;DR: It is proposed that this dynamic interaction of HP1 and MeCP2 increases their concentration at heterochromatin linking two major gene silencing pathways to stabilize transcriptional repression during differentiation.