Joachim Walter

TL;DR: It is concluded that nuclear functions in the studied cell types may not require reproducible side-by-side arrangements of specific homologous or non-homologous CTs, and that presently unknown factors may play a decisive role to enforce the different radial arrangements of large and small CTs observed in ellipsoid and spherical human cell nuclei.

TL;DR: Time lapse microscopy andletion analysis showed that Dnmt1 recruitment was mediated by the PCNA-binding domain, pointing to a direct role of DnMT1 in the restoration of epigenetic information during DNA repair.

TL;DR: Long-term live-cell studies using a HeLa cell line with GFP-tagged chromatin concluded that CT arrangements were stably maintained from mid G1 to late G2/early prophase, whereas major changes of CT neighborhoods occurred from one cell cycle to the next.

TL;DR: A role of Rad51 in recombinational repair processes of DNA damage present in postreplicative chromatin is supported by ultraviolet microirradiation experiments of small nuclear areas and whole cell ultraviolet C (UVC) irradiation experiments performed with a human fibroblast cell line.

TL;DR: Arrangements of chromosome territories in nuclei of chicken fibroblasts and neurons were analysed employing multicolour chromosome painting, laser confocal scanning microscopy and three-dimensional reconstruction to support the evolutionary conservation of several features of higher-order chromatin organization between mammals and birds.