Brian J. Lopresti

TL;DR: The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.

TL;DR: In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significantAmyloid burden can remain cognitively normal, but this finding is based on relatively small numbers and needs to be replicated in larger cohorts.

TL;DR: In the Alzheimer's disease subject who underwent PiB-PET prior to death, in vivo PiB retention levels correlated directly with region-matched post-mortem measures of [3H]PiB binding, insoluble Aβ peptide levels, 6-CN-PiB- and Aβ plaque load, but not with measures of NFT.

TL;DR: It was shown that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum and the Logan analysis was the method-of-choice for the PIBPET data as it proved stable, valid, and promising for future larger studies and voxel-based statistical analyses.

TL;DR: Of the simplified methods for PIB analysis examined, CAR90 provided DVR measures that were most comparable to ART90; CER90 was the most reproducible and SUVR90 produced the largest effect size.