D
Daniel P. Holt
Researcher at Johns Hopkins University
Publications - 83
Citations - 10198
Daniel P. Holt is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Amyloid & Medicine. The author has an hindex of 27, co-authored 72 publications receiving 9563 citations. Previous affiliations of Daniel P. Holt include University of Illinois at Chicago & Johns Hopkins University School of Medicine.
Papers
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Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TL;DR: The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
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Synthesis and evaluation of 11c-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
Chester A. Mathis,Yanming Wang,Daniel P. Holt,Guo Feng Huang,Manik L. Debnath,William E. Klunk +5 more
TL;DR: In vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition, and indicate the selective binding of the compound to amyloid plaques and cerebrovascular amyloids.
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Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B:
Julie C. Price,William E. Klunk,Brian J. Lopresti,Xueling Lu,Jessica A. Hoge,Scott K. Ziolko,Daniel P. Holt,Carolyn C. Meltzer,Steven T. DeKosky,Chester A. Mathis +9 more
TL;DR: It was shown that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum and the Logan analysis was the method-of-choice for the PIBPET data as it proved stable, valid, and promising for future larger studies and voxel-based statistical analyses.
Journal ArticleDOI
PET imaging of serotonin 1A receptor binding in depression
Wayne C. Drevets,Ellen Frank,Julie C. Price,David J. Kupfer,Daniel P. Holt,Phil J. Greer,Yiyun Huang,Clara Gautier,Chester A. Mathis +8 more
TL;DR: Serotonin-1A receptor BP is abnormally decreased in the depressed phase of familial mood disorders in multiple brain regions and may be associated with histopathological changes involving the raphe, convergence evidence from postmortem studies of mood disorders suggests.
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Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
William E. Klunk,Yanming Wang,Guo Feng Huang,Manik L. Debnath,Daniel P. Holt,Chester A. Mathis +5 more
TL;DR: The combination of relatively high affinity for amyloid, specificity for staining plaques and neurofibrillary tangles in post-mortem AD brain, and good brain entry and clearance makes [N-methyl-11C]6-Me-BTA-1 a promising candidate as an in vivo positron emission tomography (PET) beta-sheet imaging agent.