M
Manik L. Debnath
Researcher at University of Pittsburgh
Publications - 42
Citations - 9523
Manik L. Debnath is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Amyloid & Senile plaques. The author has an hindex of 22, co-authored 42 publications receiving 8941 citations.
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Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TL;DR: The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
Journal ArticleDOI
Synthesis and evaluation of 11c-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
Chester A. Mathis,Yanming Wang,Daniel P. Holt,Guo Feng Huang,Manik L. Debnath,William E. Klunk +5 more
TL;DR: In vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition, and indicate the selective binding of the compound to amyloid plaques and cerebrovascular amyloids.
Journal ArticleDOI
Post-mortem Correlates of in Vivo PiB-PET Amyloid Imaging in a Typical Case of Alzheimer's Disease
Milos D. Ikonomovic,William E. Klunk,Eric E. Abrahamson,Chester A. Mathis,Julie C. Price,Nicholas D. Tsopelas,Brian J. Lopresti,Scott K. Ziolko,Wenzhu Bi,William R. Paljug,Manik L. Debnath,Caroline E. Hope,Barbara A. Isanski,Ronald L. Hamilton,Steven T. DeKosky +14 more
TL;DR: In the Alzheimer's disease subject who underwent PiB-PET prior to death, in vivo PiB retention levels correlated directly with region-matched post-mortem measures of [3H]PiB binding, insoluble Aβ peptide levels, 6-CN-PiB- and Aβ plaque load, but not with measures of NFT.
Journal ArticleDOI
Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue
Marta Marquié,Marta Marquié,Marc D. Normandin,Charles R. Vanderburg,Isabel Costantino,Elizabeth Bien,Lisa G. Rycyna,William E. Klunk,Chester A. Mathis,Milos D. Ikonomovic,Milos D. Ikonomovic,Manik L. Debnath,Neil Vasdev,Bradford C. Dickerson,Stephen N. Gomperts,John H. Growdon,Keith A. Johnson,Matthew P. Frosch,Bradley T. Hyman,Teresa Gomez-Isla +19 more
TL;DR: The authors examined region and substrate-specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament-tau-containing lesions, and to determine whether there is off-target binding to other amyloid/non-amyloid proteins.
Journal ArticleDOI
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
William E. Klunk,Yanming Wang,Guo Feng Huang,Manik L. Debnath,Daniel P. Holt,Chester A. Mathis +5 more
TL;DR: The combination of relatively high affinity for amyloid, specificity for staining plaques and neurofibrillary tangles in post-mortem AD brain, and good brain entry and clearance makes [N-methyl-11C]6-Me-BTA-1 a promising candidate as an in vivo positron emission tomography (PET) beta-sheet imaging agent.