Y
Yanming Wang
Researcher at University of Pittsburgh
Publications - 38
Citations - 7862
Yanming Wang is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Amyloid & Senile plaques. The author has an hindex of 19, co-authored 37 publications receiving 7417 citations. Previous affiliations of Yanming Wang include University of Illinois at Chicago.
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Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TL;DR: The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
Journal ArticleDOI
Synthesis and evaluation of 11c-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
Chester A. Mathis,Yanming Wang,Daniel P. Holt,Guo Feng Huang,Manik L. Debnath,William E. Klunk +5 more
TL;DR: In vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition, and indicate the selective binding of the compound to amyloid plaques and cerebrovascular amyloids.
Journal ArticleDOI
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
William E. Klunk,Yanming Wang,Guo Feng Huang,Manik L. Debnath,Daniel P. Holt,Chester A. Mathis +5 more
TL;DR: The combination of relatively high affinity for amyloid, specificity for staining plaques and neurofibrillary tangles in post-mortem AD brain, and good brain entry and clearance makes [N-methyl-11C]6-Me-BTA-1 a promising candidate as an in vivo positron emission tomography (PET) beta-sheet imaging agent.
Journal ArticleDOI
Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy-X04, a Systemically Administered Congo Red Derivative
William E. Klunk,Brian J. Bacskai,Chester A. Mathis,Stephen T. Kajdasz,Megan E. McLellan,Matthew P. Frosch,Manik L. Debnath,Daniel P. Holt,Yanming Wang,Bradley T. Hyman +9 more
TL;DR: Complementary quantitative studies using tracer doses of carbon-11-labeled methoxy-X04 show that it enters rat brain in amounts that suggest it is a viable candidate as a positron emission tomography (PET) amyloid-imaging agent for in vivo human studies.
Journal ArticleDOI
A Lipophilic Thioflavin-T Derivative for Positron Emission Tomography (PET) Imaging of Amyloid in Brain
Chester A. Mathis,Brian J. Bacskai,Stephen T. Kajdasz,Megan E. McLellan,Matthew P. Frosch,Bradley T. Hyman,Daniel P. Holt,Yanming Wang,Guo Feng Huang,Manik L. Debnath,William E. Klunk +10 more
TL;DR: Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6, indicating that [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease.