C
Christian R. H. Raetz
Researcher at Merck & Co.
Publications - 30
Citations - 7021
Christian R. H. Raetz is an academic researcher from Merck & Co.. The author has contributed to research in topics: Lipid A & Escherichia coli. The author has an hindex of 25, co-authored 30 publications receiving 6553 citations. Previous affiliations of Christian R. H. Raetz include Duke University.
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Journal ArticleDOI
A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
Journal ArticleDOI
Biochemistry of endotoxins.
TL;DR: Interaction of LPS with Polyvalent Cations and the Inner Core: Interaction of Chemotypes and the Outer Core.
Journal ArticleDOI
A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A structured vocabulary will facilitate the systematization of lipid biology and enable the cataloging of lipids and their properties in a way that is compatible with other macromolecular databases.
Journal ArticleDOI
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction.
Christian R. H. Raetz,Richard Ulevitch,Samuel D. Wright,Carol H. Sibley,Aihao Ding,Carl Nathan +5 more
TL;DR: This review summarizes the essentials of endotoxin biochemistry and presents recent experiments aimed at identifying surface receptors, signal‐transducing elements, transcriptional factors, and key intracellular targets involved in the response of animal cells to endotoxins.
Journal ArticleDOI
Recognition and plasma clearance of endotoxin by scavenger receptors.
TL;DR: In vivo studies show that scavenger-receptor ligands greatly inhibit hepatic uptake of lipid IVA in mice, and scavenger receptors expressed on macrophages may have an important role in the clearance and detoxification of endotoxin in animals.