T
Takao Shimizu
Researcher at University of Tokyo
Publications - 554
Citations - 38595
Takao Shimizu is an academic researcher from University of Tokyo. The author has contributed to research in topics: Receptor & Leukotriene B4. The author has an hindex of 93, co-authored 518 publications receiving 35706 citations. Previous affiliations of Takao Shimizu include Kyoto University & Gifu University.
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Journal ArticleDOI
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,Atsushi Tsuchida,Takehiko Yokomizo,Takehiko Yokomizo,Shunbun Kita,Takuya Sugiyama,Makoto Miyagishi,Makoto Miyagishi,Kazuo Hara,Masaki Tsunoda,Koji Murakami,Toshiaki Ohteki,S. Uchida,Sato Takekawa,Hironori Waki,Nelson H. Tsuno,Yoichi Shibata,Yasuo Terauchi,Philippe Froguel,Kazuyuki Tobe,Shigeo Koyasu,Kazunari Taira,Kazunari Taira,Toshio Kitamura,Takao Shimizu,Takao Shimizu,Ryozo Nagai,Takashi Kadowaki +29 more
TL;DR: The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
Journal ArticleDOI
A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
Journal ArticleDOI
Update of the LIPID MAPS comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,Robert C. Murphy,Masahiro Nishijima,Christian R. H. Raetz,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael J.O. Wakelam,Edward A. Dennis +9 more
TL;DR: The International Lipid Classification and Nomenclature Committee under the sponsorship of the LIPID MAPS Consortium developed and established a "Comprehensive Classification System for Lipids" based on well defined chemical and biochemical principles and using an ontology that is extensible, flexible, and scalable as mentioned in this paper.
Journal ArticleDOI
A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.
TL;DR: The cloning of the complementary DNA encoding a cell-surface LTB4 receptor that is highly expressed in human leukocytes is reported, showing that L TB4 is a unique lipid mediator that interacts with both cell- surface and nuclear receptors.
Journal ArticleDOI
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Masato Iwabu,Toshimasa Yamauchi,Miki Okada-Iwabu,Koji Sato,Tatsuro Nakagawa,Masaaki Funata,Mamiko Yamaguchi,Shigeyuki Namiki,Ryo Nakayama,Mitsuhisa Tabata,Hitomi Ogata,Naoto Kubota,Iseki Takamoto,Yukiko K. Hayashi,Naoko Yamauchi,Hironori Waki,Masashi Fukayama,Ichizo Nishino,Kumpei Tokuyama,Kohjiro Ueki,Yuichi Oike,Satoshi Ishii,Kenzo Hirose,Takao Shimizu,Kazushige Touhara,Takashi Kadowaki +25 more
TL;DR: Evidence is provided that adiponectin induces extracellular Ca2+ influx by AdipoR1, which was necessary for subsequent activation of Ca2-/calmodulin-dependent protein kinase kinase β (CaMKKβ), AMPK and SIRT1, increased expression and decreased acetylation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1 α), and increased mitochondria in myocytes.