H
H. Alex Brown
Researcher at Vanderbilt University
Publications - Ā 127
Citations - Ā 11075
H. Alex Brown is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Phosphatidic acid & Phospholipase D. The author has an hindex of 53, co-authored 111 publications receiving 9918 citations. Previous affiliations of H. Alex Brown include McMaster University & Veterans Health Administration.
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Journal ArticleDOI
A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
Journal ArticleDOI
ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity
TL;DR: The current finding suggests that PLD activity plays a prominent role in the action of ARF and that ARF may be a key component in the generation of second messengers via phospholipase D.
Journal ArticleDOI
A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A structured vocabulary will facilitate the systematization of lipid biology and enable the cataloging of lipids and their properties in a way that is compatible with other macromolecular databases.
Journal ArticleDOI
Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses
Nathanael J. Spann,Lana X. Garmire,Jeffrey G. McDonald,David S. Myers,Stephen B. Milne,Norihito Shibata,Donna Reichart,Jesse N. Fox,Iftach Shaked,Daniel Heudobler,Christian R. H. Raetz,Elaine W. Wang,Samuel Kelly,M. Cameron Sullards,Robert C. Murphy,Alfred H. Merrill,H. Alex Brown,Edward A. Dennis,Andrew C. Li,Klaus Ley,Sotirios Tsimikas,Eoin Fahy,Shankar Subramaniam,Oswald Quehenberger,David W. Russell,Christopher K. Glass +25 more
TL;DR: Observations suggest that macrophage activation in atherosclerotic lesions results from extrinsic, proinflammatory signals generated within the artery wall that suppress homeostatic and anti-inflammatory functions of desmosterol.
Journal ArticleDOI
The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.
Manya Warrier,Diana M. Shih,Amy C. Burrows,Daniel Ferguson,Anthony D. Gromovsky,Amanda L. Brown,Stephanie M. Marshall,Allison L. McDaniel,Rebecca C. Schugar,Zeneng Wang,Jessica Sacks,Xin Rong,Thomas Q. de Aguiar Vallim,Jeff W. Chou,Pavlina T. Ivanova,David S. Myers,H. Alex Brown,Richard G. Lee,Rosanne M. Crooke,Mark J. Graham,Xiuli Liu,Paolo Parini,Peter Tontonoz,Peter Tontonoz,Aldon J. Lusis,Stanley L. Hazen,Ryan E. Temel,J. Mark Brown +27 more
TL;DR: In this article, the authors performed transcriptional profiling in mouse models of altered reverse cholesterol transport (RCT) and serendipitously identified the TMAO-generating enzyme flavin monooxygenase 3 as a powerful modifier of cholesterol metabolism and RCT.