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Ai Yamamoto

Researcher at Columbia University

Publications -  63
Citations -  17339

Ai Yamamoto is an academic researcher from Columbia University. The author has contributed to research in topics: Autophagy & Huntingtin. The author has an hindex of 29, co-authored 53 publications receiving 14423 citations. Previous affiliations of Ai Yamamoto include Columbia University Medical Center.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease

Ai Yamamoto, +2 more
- 31 Mar 2000 - 
TL;DR: It is demonstrated that a continuous influx of the mutant protein is required to maintain inclusions and symptoms of Huntington's disease, raising the possibility that HD may be reversible.
Journal ArticleDOI

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

Guomei Tang, +17 more
- 03 Sep 2014 - 
TL;DR: This work reports increased dendritic spine density with reduced developmental spine pruning in layer V pyramidal neurons in postmortem ASD temporal lobe and suggests that mTOR-regulated autophagy is required for developmental spinePruning, and activation of neuronal Autophagy corrects synaptic pathology and social behavior deficits in ASD models with hyperactivated mTOR.