Ling-Xian Yi

TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.

TL;DR: A relatively high prevalence of S. aureus with less antimicrobial resistance but often positive for enterotoxigenicity and biofilm formation is found in raw milk of dairy cows with mastitis in Beijing, China.

TL;DR: It is concluded that IncI2, IncX4, and IncHI2 were the major plasmid types driving the dissemination of mcr-1 in this farm and worldwide and increased fitness or co-selection by other antimicrobials might contribute to the further dissemination of the three epidemic mCr-1–positive plasmids.

TL;DR: Li et al. as discussed by the authors investigated the regulatory mechanism for controlling the fitness cost of an IncI2 plasmid carrying colistin resistance gene mcr-1 and found that maintaining mcr1 at a single copy is essential for its persistence.

TL;DR: The dissemination of almost identical blaNDM-5-bearing F36:A-:B32 and bla NDM-7-bearing IncX3 plasmids in different countries highlights the importance of international trade and travel in the spread of antimicrobial resistance strains and plasmid worldwide.