T
Timothy R. Walsh
Researcher at University of Oxford
Publications - 330
Citations - 38358
Timothy R. Walsh is an academic researcher from University of Oxford. The author has contributed to research in topics: Plasmid & Gene. The author has an hindex of 77, co-authored 305 publications receiving 30554 citations. Previous affiliations of Timothy R. Walsh include Southmead Hospital & China Agricultural University.
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Journal ArticleDOI
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study
Yiyun Liu,Yang Wang,Timothy R. Walsh,Ling-Xian Yi,Rong Zhang,James Spencer,Yohei Doi,Guo-Bao Tian,Baolei Dong,Xianhui Huang,Lin-Feng Yu,Danxia Gu,Hongwei Ren,Xiaojie Chen,Luchao Lv,Dandan He,Hongwei Zhou,Zi-sen Liang,Jian-Hua Liu,Jianzhong Shen +19 more
TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.
Journal ArticleDOI
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Karthikeyan Kumarasamy,Mark Toleman,Timothy R. Walsh,Jay Bagaria,Fafhana Butt,Ravikumar Balakrishnan,Uma Chaudhary,Michel Doumith,Christian G. Giske,Seema Irfan,Padma Krishnan,Anil Kumar,Sunil Maharjan,Shazad Mushtaq,Tabassum Noorie,David L. Paterson,A. Pearson,Claire Perry,Rachel Pike,Bhargavi Rao,Ujjwayini Ray,Jayanta B. Sarma,Madhu Sharma,Elizabeth Sheridan,M A Thirunarayan,Jane F. Turton,Supriya Upadhyay,Marina Warner,William Welfare,David M. Livermore,Neil Woodford +30 more
TL;DR: The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed.
Journal ArticleDOI
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Christopher J L Murray,Kevin S Ikuta,Fablina Sharara,Lucien Swetschinski,Gisela Robles Aguilar,Authia Gray,Chieh Fei Han,Catherine Bisignano,Puja C Rao,Eve E. Wool,Sarah Charlotte Johnson,Annie J. Browne,Michael G. Chipeta,Frederick Fell,Sean Hackett,Georgina Haines-Woodhouse,Bahar H. Kashef Hamadani,Emmanuelle A. P. Kumaran,Barney McManigal,Sureeruk Achalapong,Ramesh Agarwal,Samuel Akech,Samuel B. Albertson,John H Amuasi,Jason R. Andrews,Aleskandr Aravkin,Elizabeth A. Ashley,François-Xavier Babin,Freddie Bailey,Stephen Baker,Buddha Basnyat,Adrie Bekker,Rose G Bender,James A. Berkley,Adhisivam Bethou,Julia Bielicki,Suppawat Boonkasidecha,James Bukosia,Cristina Gardony Carvalheiro,Carlos A Castañeda-Orjuela,Vilada Chansamouth,Suman Chaurasia,Sara Chiurchiù,Fazle Rabbi Chowdhury,Rafai Clotaire Donatien,Aislinn Cook,Ben S. Cooper,Tim R. Cressey,Elia Criollo-Mora,Matthew Cunningham,Saffiatou Darboe,Nicholas P. J. Day,Maia De Luca,Klara Dokova,Angela Dramowski,Susanna Dunachie,Thuy Duong Bich,Tim Eckmanns,Daniel Eibach,Amir Emami,Nicholas A. Feasey,Natasha Fisher-Pearson,Karen Forrest,Coralith Garcia,Denise O Garrett,Petra Gastmeier,Ababi Zergaw Giref,Rachel C Greer,Vikas Gupta,Sebastian Haller,Andrea Haselbeck,Simon I. Hay,M. Holm,Susan Hopkins,Yingfen Hsia,Kenneth Iregbu,Jan Jacobs,Daniel Jarovsky,Fatemeh Javanmardi,Adam Jenney,Meera Khorana,Suwimon Khusuwan,Niranjan Kissoon,Elsa Kobeissi,Tomislav Kostyanev,Fiorella Krapp,Ralf Krumkamp,Ajay Kumar,Hmwe H Kyu,Cherry Lim,Kruy Lim,Direk Limmathurotsakul,Michael J. Loftus,Miles Lunn,Jianing Ma,Anand Manoharan,Florian Marks,Jürgen May,Mayfong Mayxay,Neema Mturi,Tatiana Múnera-Huertas,Patrick Musicha,Lilian Musila,Marisa Márcia Mussi-Pinhata,Ravi Naidu,Tomoka Nakamura,Ruchi Nanavati,Sushma Nangia,Paul N. Newton,Chanpheaktra Ngoun,Amanda Novotney,Davis Nwakanma,Christina W. Obiero,Theresa J. Ochoa,Antonio Olivas-Martinez,Piero Olliaro,Edna Ooko,Edgar Ortiz-Brizuela,Pradthana Ounchanum,Gi Deok Pak,Jose Luis Paredes,Anton Y. Peleg,Carlo Perrone,Thong Phe,Koukeo Phommasone,Nishad Plakkal,Alfredo Ponce-de-León,Mathieu Raad,Tanusha Ramdin,Sayaphet Rattanavong,Amy Riddell,Tamalee Roberts,Julie V. Robotham,Anna Roca,Victor D. Rosenthal,Kristina E. Rudd,Neal Russell,Helio S. Sader,Weerawut Saengchan,Janice W. Schnall,John Anthony G Scott,Samroeng Seekaew,Mike Sharland,Madhusudhan Shivamallappa,José Sifuentes-Osornio,A. John Simpson,Nicolas Steenkeste,Andrew J. Stewardson,Temenuga Stoeva,Nidanuch Tasak,Areerat Thaiprakong,Guy E. Thwaites,Caroline Tigoi,Claudia Turner,Paul Turner,H. Rogier van Doorn,Sithembiso Velaphi,Avina Vongpradith,Manivanh Vongsouvath,Huong X. Vu,Timothy R. Walsh,Judd L. Walson,Seymour Waner,Tri Wangrangsimakul,Prapass Wannapinij,Teresa M. Wozniak,Tracey E M W Young Sharma,Kalvin C. Yu,Peng Zheng,Benn Sartorius,Alan D. Lopez,Andy Stergachis,Catrin E. Moore,Christiane Dolecek,Mohsen Naghavi +174 more
TL;DR: This study provides the first comprehensive assessment of the global burden of AMR, as well as an evaluation of the availability of data, and estimates aggregated to the global and regional level.
Journal ArticleDOI
Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India
Dongeun Yong,Mark Toleman,Christian G. Giske,Hyun Sun Cho,Kristina Sundman,Kyungwon Lee,Timothy R. Walsh +6 more
TL;DR: A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex, showing broad resistance carried on these plasmids.
Journal ArticleDOI
Multiplex PCR for detection of acquired carbapenemase genes
TL;DR: A rapid and reliable PCR-based technique was developed for detection of genes encoding carbapenemases belonging to different classes using optimized conditions, with PCR giving distinct amplicon sizes corresponding to the different genes for each mixture.