Xiaojie Chen

TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.

TL;DR: It is demonstrated that commensal E. coli from healthy food animals can be important reservoirs of bla(CTX-M) genes and may contribute to the dissemination and transfer of these β-lactamase genes throughout China.

TL;DR: The study reported the dramatic increase of CTX-M ESBLs in E. coli isolated from animals overtime in China and highlighted the need for urgent control strategies to limit the dissemination of those resistant genes in China.

TL;DR: It is concluded that IncI2, IncX4, and IncHI2 were the major plasmid types driving the dissemination of mcr-1 in this farm and worldwide and increased fitness or co-selection by other antimicrobials might contribute to the further dissemination of the three epidemic mCr-1–positive plasmids.

TL;DR: The high frequency of colistin resistance and mcr-1 gene among E. coli isolates from food animals in China urged the need to minimize potential risks of colistsin resistance development and the spread of mcr -1 gene.