EAACI Molecular Allergology User's Guide.
Paolo Maria Matricardi,Jörg Kleine-Tebbe,Hans Jürgen Hoffmann,Rudolf Valenta,Christiane Hilger,Stephanie Hofmaier,Rob C. Aalberse,Ioana Agache,Riccardo Asero,Barbara Ballmer-Weber,Domingo Barber,Kirsten Beyer,Tilo Biedermann,M. B. Bilò,Simon Blank,Barbara Bohle,Philipp P. Bosshard,Heimo Breiteneder,Helen A. Brough,Luis Caraballo,J-C Caubet,Reto Crameri,Janet M. Davies,Nikolaos Douladiris,M. Ebisawa,Philippe Eigenmann,Montserrat Fernandez-Rivas,Fatima Ferreira,Gabriele Gadermaier,Martin Glatz,Robert G. Hamilton,Thomas Hawranek,P W Hellings,Karin Hoffmann-Sommergruber,Thilo Jakob,Uta Jappe,Marek Jutel,Sandip D. Kamath,Edward F. Knol,Peter Korošec,Annette Kuehn,Gideon Lack,Gideon Lack,Andreas L. Lopata,Mika J. Mäkelä,Martine Morisset,Verena Niederberger,Anna Nowak-Wegrzyn,Nikolaos G. Papadopoulos,Elide A. Pastorello,Gabrielle Pauli,Thomas A.E. Platts-Mills,Daniela Posa,Lars K. Poulsen,Monika Raulf,Joaquín Sastre,Enrico Scala,Johannes Schmid,Peter Schmid-Grendelmeier,M. van Hage,R. van Ree,Stefan Vieths,Richard W. Weber,Magnus Wickman,Antonella Muraro,Markus Ollert +65 more
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The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) as mentioned in this paper provides comprehensive information on important allergens and describes the diagnostic options using component-resolved diagnosis (CRD).Abstract:
The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.read more
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Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy
TL;DR: To evaluate strategies of early peanut consumption or avoidance for prevention of peanut allergy in patients at risk, 640 patients from severe eczema, egg allergy, or both were evaluated over a 60-month period.
Journal ArticleDOI
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.
Sarah K. Wise,Sandra Y. Lin,Elina Toskala,Richard R. Orlandi,Cezmi A. Akdis,Jeremiah A. Alt,Antoine Azar,Fuad M. Baroody,Claus Bachert,G. Walter Canonica,Thomas Chacko,Cemal Cingi,Giorgio Ciprandi,Jacquelynne P. Corey,Linda Cox,Peter S. Creticos,Adnan Custovic,Cecelia Damask,Adam S. DeConde,John M. DelGaudio,Charles S. Ebert,Jean Anderson Eloy,Carrie E. Flanagan,Wytske Fokkens,Christine B. Franzese,Jan Gosepath,Ashleigh A. Halderman,Robert G. Hamilton,Hans Jürgen Hoffman,Jens M. Hohlfeld,Steven M. Houser,Peter H. Hwang,Cristoforo Incorvaia,Deborah Jarvis,Ayesha N. Khalid,Maritta Kilpeläinen,Todd T. Kingdom,Helene J. Krouse,Désirée Larenas-Linnemann,Adrienne M. Laury,Stella E. Lee,Joshua M. Levy,Amber U Luong,Bradley F. Marple,Edward D. McCoul,K. Christopher McMains,Erik Melén,James W. Mims,Gianna Moscato,Joaquim Mullol,Harold S. Nelson,Monica O. Patadia,Ruby Pawankar,Oliver Pfaar,Michael P. Platt,William R. Reisacher,Carmen Rondon,Luke Rudmik,Matthew W. Ryan,Joaquín Sastre,Rodney J. Schlosser,Russell A Settipane,Hemant Sharma,Aziz Sheikh,Timothy L. Smith,Pongsakorn Tantilipikorn,Jody R. Tversky,Maria C Veling,De Yun Wang,Marit Westman,Magnus Wickman,Mark A. Zacharek +71 more
TL;DR: To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).
Journal ArticleDOI
Oral Immunotherapy for Treatment of Egg Allergy in Children
TL;DR: To determine that oral immunotherapy (OIT) to egg is safe and effective to desensitize patients and induce sustained unresponsiveness, a double-blind, randomized placebo-controlled study of 55 children, sensitive to egg, is conducted.
Journal ArticleDOI
Clinical phenotypes and endophenotypes of atopic dermatitis: Where are we, and where should we go?
Thomas Bieber,Thomas Bieber,Angelo Massimiliano D'Erme,Cezmi A. Akdis,Claudia Traidl-Hoffmann,Roger Lauener,Georg Schäppi,Peter Schmid-Grendelmeier +7 more
TL;DR: A systems biology approach merging the numerous clinical phenotypes with robust biomarkers will be needed to best exploit their potential significance for the future molecular taxonomy of AD.
Journal ArticleDOI
IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.
Ignacio J. Ansotegui,Giovanni Melioli,Giorgio Walter Canonica,Luis Caraballo,Elisa Villa,Motohiro Ebisawa,Giovanni Passalacqua,Eleonora Savi,Didier G. Ebo,R. Maximiliano Gómez,Olga Sánchez,John Oppenheimer,Erika Jensen-Jarolim,David A. Fischer,Tari Haahtela,Martti Anton Antila,Jean Bousquet,Victoria Cardona,Wen Chin Chiang,Pascal Demoly,Pascal Demoly,Lawrence M. DuBuske,Marta Ferrer Puga,Roy Gerth van Wijk,Sandra Nora González Díaz,Alexei Gonzalez-Estrada,Edgardo Jares,Ayse Fusun Kalpaklioglu,Luciana Kase Tanno,Marek L. Kowalski,Dennis K. Ledford,Olga Patricia Monge Ortega,Mario Morais Almeida,Oliver Pfaar,Lars K. Poulsen,Ruby Pawankar,Harald Renz,Antonino Romano,Nelson Augusto Rosário Filho,Lanny J. Rosenwasser,Mario Sanchez Borges,Enrico Scala,Gianenrico Senna,Juan Carlos Sisul,Mimi L.K. Tang,Bernard Yu-Hor Thong,Rudolf Valenta,Rudolf Valenta,Robert A. Wood,Torsten Zuberbier +49 more
TL;DR: A thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro, and discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy.
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TL;DR: The genome sequence of the honeybee Apis mellifera is reported, suggesting a novel African origin for the species A. melliferA and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.
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