A
Adam C. Gower
Researcher at Boston University
Publications - 75
Citations - 3669
Adam C. Gower is an academic researcher from Boston University. The author has contributed to research in topics: Gene expression profiling & Gene. The author has an hindex of 28, co-authored 68 publications receiving 2903 citations. Previous affiliations of Adam C. Gower include Boston Medical Center.
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Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity.
Cary B. Aarons,Philip A. Cohen,Adam C. Gower,Karen L. Reed,Susan E. Leeman,Arthur F. Stucchi,James M. Becker +6 more
TL;DR: It is suggested that statins administered within the peritoneum can up-regulate local fibrinolysis, while the in vitro studies show that this effect may be mediated, in part, by intermediates of the cholesterol biosynthetic pathway that regulate Rho protein signaling.
Journal ArticleDOI
Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Jennifer Beane,Jessica Vick,Frank Schembri,Christina Anderlind,Adam C. Gower,Joshua D. Campbell,Lingqi Luo,Xiaohui Zhang,Ji Xiao,Yuriy O. Alekseyev,Shenglong Wang,Shawn Levy,Pierre P. Massion,Marc E. Lenburg,Avrum Spira +14 more
TL;DR: It is demonstrated that transcriptome sequencing has the potential to provide new insights into the biology of the airway field of injury associated with smoking and lung cancer and to identify additional biomarkers of lung cancer risk and novel targets for chemoprevention.
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Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.
Vida Chitsazzadeh,Cristian Coarfa,Jennifer Drummond,Tri H. Nguyen,Aaron K. Joseph,Suneel Chilukuri,Elizabeth Charpiot,Charles H. Adelmann,Grace Ching,Tran N. Nguyen,Courtney Nicholas,Valencia Thomas,Michael R. Migden,Deborah F. MacFarlane,Erika Thompson,Jianjun Shen,Yoko Takata,Kayla McNiece,Maxim Polansky,Hussein A. Abbas,Kimal Rajapakshe,Adam C. Gower,Avrum Spira,Kyle R. Covington,Weimin Xiao,Preethi H. Gunaratne,Curtis R. Pickering,Mitchell J. Frederick,Jeffrey N. Myers,Li Shen,Hui Yao,Xiaoping Su,Ronald P. Rapini,Ronald P. Rapini,David A. Wheeler,Ernest T. Hawk,Elsa R. Flores,Kenneth Y. Tsai +37 more
TL;DR: It is demonstrated thatcuSCC bears deep molecular similarities to multiple carcinogen-driven SCCs from diverse sites, suggesting that cuSCC may serve as an effective, accessible model for multiple SCC types and that common treatment and prevention strategies may be feasible.
Journal ArticleDOI
A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity
Karen L. Reed,A. Brent Fruin,Adam C. Gower,Arthur F. Stucchi,Susan E. Leeman,James M. Becker +5 more
TL;DR: It is suggested that activation of the NK-1R promotes peritoneal adhesion formation by limiting fibrinolytic activity in the postoperative peritoneum, thus enabling fibrinous adhesions to persist.